About: Anti HSV-1 Activity of Halistanol Sulfate and Halistanol Sulfate C Isolated from Brazilian Marine Sponge Petromica citrina (Demospongiae)

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About: Anti HSV-1 Activity of Halistanol Sulfate and Halistanol Sulfate C Isolated from Brazilian Marine Sponge Petromica citrina (Demospongiae) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Anti HSV-1 Activity of Halistanol Sulfate and Halistanol Sulfate C Isolated from Brazilian Marine Sponge Petromica citrina (Demospongiae)
Creator	Cabrera, Gabriela Rigotto, Caroline Flávio, Henrique Reginatto, Schenkel, Paulo Bianco, Éverson Da, Tatiana Goulart Moritz, Maria Guillermo Quiroz, Carlos Guimarães, Rosa Luí S Carraro, João Oliveira Simões, Cláudia Palermo, Jorge Quintana De Oliveira, Simone Rojo De Almeida, Maria
Source	Medline; PMC
abstract	The n-butanol fraction (BF) obtained from the crude extract of the marine sponge Petromica citrina, the halistanol-enriched fraction (TSH fraction), and the isolated compounds halistanol sulfate (1) and halistanol sulfate C (2), were evaluated for their inhibitory effects on the replication of the Herpes Simplex Virus type 1 (HSV-1, KOS strain) by the viral plaque number reduction assay. The TSH fraction was the most effective against HSV-1 replication (SI = 15.33), whereas compounds 1 (SI = 2.46) and 2 (SI = 1.95) were less active. The most active fraction and these compounds were also assayed to determine the viral multiplication step(s) upon which they act as well as their potential synergistic effects. The anti-HSV-1 activity detected was mediated by the inhibition of virus attachment and by the penetration into Vero cells, the virucidal effect on virus particles, and by the impairment in levels of ICP27 and gD proteins of HSV-1. In summary, these results suggest that the anti-HSV-1 activity of TSH fraction detected is possibly related to the synergic effects of compounds 1 and 2.
has issue date	2013-10-29(xsd:dateTime)
bibo:doi	10.3390/md11114176
bibo:pmid	24172213
has license	cc-by
sha1sum (hex)	2f4331d2427906e96afeb82ef5c4a90dda236470
schema:url	https://doi.org/10.3390/md11114176
resource representing a document's title	Anti HSV-1 Activity of Halistanol Sulfate and Halistanol Sulfate C Isolated from Brazilian Marine Sponge Petromica citrina (Demospongiae)
has PubMed Central identifier	PMC3853722
has PubMed identifier	24172213
schema:publication	Mar Drugs
resource representing a document's body	covid:2f4331d2427906e96afeb82ef5c4a90dda236470#body_text
is schema:about of	covid:arg/2f4331d2427906e96afeb82ef5c4a90dda236470 named entity 'HSV-1' named entity 'Sulfate' named entity 'chemical shift' named entity 'HSV-1' named entity 'mesylate' named entity 'influenza virus' named entity 'methyl' named entity 'pharmacological properties' named entity 'viral replication' named entity 'PFU' named entity 'synergic' named entity 'sulfate' named entity 'Vero cells' named entity 'PFU' named entity 'Vero cell' named entity 'Bruker' named entity 'TSH' named entity 'mode of action' named entity 'sulfated' named entity 'MeOH' named entity 'TSH' named entity 'cytotoxic' named entity 'chromatography' named entity 'late proteins' named entity 'methyl' named entity 'sulfate' named entity 'TSH' named entity 'reversed-phase' named entity 'column chromatography' named entity 'adsorbed' named entity 'charge density' named entity 'ACV' named entity 'monoclonal antibody' named entity 'antiviral' named entity 'receptor' named entity 'TSH' named entity 'HSV-1' named entity '4.83' named entity 'sulfates' named entity 'HSV' named entity 'HSV-2' named entity 'virus' named entity 'France' named entity 'Vero cell' named entity 'non-fat' named entity 'HIV-2' named entity 'plaque forming units' named entity 'University of Rennes' named entity 'St. Louis' named entity 'biological activities' named entity 'HMBC' named entity 'herpes' named entity 'experimental design' named entity 'HIV' named entity 'Western blotting' named entity 'viral plaque' named entity 'mass spectrometer' named entity 'virucidal' named entity 'proton' named entity 'antiviral activity' named entity 'sulfate' named entity 'HSV-1' named entity 'Vero cell' named entity 'sulfates' named entity 'serum' named entity 'biological properties'

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