About: The role of genetic variants in human longevity

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The role of genetic variants in human longevity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The role of genetic variants in human longevity
Creator	Chen, Liang-Kung Chung, Wen-Hung Dao, Ro-Lan Hung, Shuen-Iu
Source	Elsevier; Medline; PMC
abstract	Human longevity is a complex phenotype with a strong genetic predisposition. Increasing evidence has revealed the genetic antecedents of human longevity. This article aims to review the data of various case/control association studies that examine the difference in genetic polymorphisms between long-lived people and younger subjects across different human populations. There are more than 100 candidate genes potentially involved in human longevity; this article particularly focuses on genes of the insulin/IGF-1 pathway, FOXO3A, FOXO1A, lipoprotein metabolism (e.g., APOE and PON1), and cell-cycle regulators (e.g., TP53 and P21). Since the confirmed genetic components for human longevity are few to date, further precise assessment of the genetic contributions is required. Gaining a better understanding of the contribution of genetics to human longevity may assist in the design of improved treatment methods for age-related diseases, delay the aging process, and, ultimately, prolong the human lifespan.
has issue date	2010-08-12(xsd:dateTime)
bibo:doi	10.1016/j.arr.2010.08.001
bibo:pmid	20708717
has license	no-cc
sha1sum (hex)	2f70fc601b4d40ff368df47cf606721f7212c635
schema:url	https://doi.org/10.1016/j.arr.2010.08.001
resource representing a document's title	The role of genetic variants in human longevity
has PubMed Central identifier	PMC7105197
has PubMed identifier	20708717
schema:publication	Ageing Res Rev
resource representing a document's body	covid:2f70fc601b4d40ff368df47cf606721f7212c635#body_text
is schema:about of	named entity 'This' named entity 'ultimately' named entity 'focuses' named entity 'cell-cycle' named entity 'genetic' named entity 'P21' named entity 'FOXO1A' named entity 'METHODS' named entity 'BETTER' named entity 'HUMAN' named entity 'INSULIN' named entity 'YOUNGER' named entity 'REVIEW' named entity 'APOE' named entity 'REGULATORS' named entity 'ACROSS' named entity 'GAINING' named entity 'LIPOPROTEIN METABOLISM' named entity 'INVOLVED' named entity 'REQUIRED' named entity 'IMPROVED' named entity 'PRECISE' named entity 'AGE' named entity 'FOXO3A' named entity 'ASSESSMENT' named entity 'DESIGN' named entity 'PROLONG' named entity 'ASSOCIATION' named entity 'LONG' named entity 'GENES' named entity 'TP53' named entity 'VARIANTS' named entity 'IS A' named entity 'DATA' named entity 'VARIOUS' named entity 'GENETIC' named entity 'PATHWAY' named entity 'HUMAN' named entity 'GENETIC' named entity 'TREATMENT' named entity 'CONFIRMED' named entity 'MORE THAN' named entity 'STUDIES' named entity 'PEOPLE' named entity 'STRONG' named entity 'CASE' named entity 'CANDIDATE GENES' named entity 'DIFFERENCE' named entity 'DATE' named entity 'ASSIST' named entity 'LIFESPAN' named entity 'EVIDENCE' named entity 'POLYMORPHISMS' named entity 'DIFFERENT' named entity 'SUBJECTS' named entity 'CONTRIBUTION' named entity 'REVEALED' named entity 'GENETICS' named entity 'AGING PROCESS' named entity 'RELATED' named entity 'ANTECEDENTS' named entity 'P21' named entity 'POPULATIONS' named entity 'GENETIC PREDISPOSITION' named entity 'PON1' named entity 'LONGEVITY' named entity 'AIMS' named entity 'INCREASING' named entity 'ARTICLE' named entity 'DISEASES' named entity 'CELL-CYCLE' named entity 'COMPONENTS' named entity 'ROLE' named entity 'DELAY' named entity 'UNDERSTANDING' named entity 'LONGEVITY' named entity 'COMPLEX' named entity '100'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software