About: Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing

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About: Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing
Creator	Hayden, Frederick Carper, Holliday Murphy, Deborah Patrie, James Platts-Mills, Thomas Shaker, Marcus Chamberlain, Rachel Hellems, Martha Peerzada, Jehanna Heymann, Peter Erwin, Elizabeth Hatley, Tina Mclaughlin, Anne
Source	Elsevier; Medline; PMC
abstract	Abstract Background Viral respiratory tract infections and atopy are associated with attacks of wheezing during childhood. However, information about the relationship between viral infections and atopy among children whose attacks of wheezing lead to hospitalization is unclear. Objective To evaluate the prevalence of viral respiratory tract pathogens among infants and children hospitalized for wheezing and to analyze the results in relation to the patient's age, atopic characteristics, and season of admission. Methods This was a case-control study of children (age 2 months to 18 years) admitted for wheezing to the University of Virginia Medical Center over a period of 12 months. Children without wheezing were enrolled as controls. Nasal secretions were evaluated for viral pathogens by using cultures, PCR tests, and antigen detection. Total IgE and specific IgE antibody to common aeroallergens was measured in serum. Results Seventy percent of children hospitalized for wheezing before age 3 years (n=79) were admitted between December and March, whereas 46% of children age 3 to 18 years (n=54) were hospitalized between September and November. Among children younger than 3 years, viral pathogens were detected in 84% (66/79) of wheezing children and 55% (42/77) of controls (P < .001). Respiratory syncytial virus was the dominant pathogen during the winter months, but rhinovirus was more common during other months. Total serum IgE levels were generally low, and values from wheezing and control subjects overlapped considerably. Among children 3 years and older, 61% (33/54) of subjects admitted for wheezing tested positive for virus (predominantly rhinovirus), compared with 21% (12/56) of controls (P < .001). The total serum IgE values among wheezing children (geometric mean, 386 IU/mL; 95% CI, 259-573) were substantially elevated compared with those of controls (geometric mean, 38 IU/mL; 95% CI, 26-56; P < .001). A significantly higher percentage of wheezing children compared with controls was sensitized to at least 1 of the inhaled allergens tested: 84% (36/43) compared with 33% (15/45; P < .001). The atopic characteristics of wheezing children who tested positive or negative for virus were similar. Conclusions Viral infections were the dominant risk factor for wheezing among children hospitalized before 3 years of age. By comparison, a large majority of the wheezing children age 3 to 18 years had striking atopic characteristics that may be critical as a risk factor for hospitalization and an adverse response to viral infections, especially infections caused by rhinovirus.
has issue date	2004-08-31(xsd:dateTime)
bibo:doi	10.1016/j.jaci.2004.04.006
bibo:pmid	15316497
has license	els-covid
sha1sum (hex)	2f739ce158fe0605ca31cd2b83e00abfba4c6823
schema:url	https://doi.org/10.1016/j.jaci.2004.04.006
resource representing a document's title	Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing
has PubMed Central identifier	PMC7185400
has PubMed identifier	15316497
schema:publication	Journal of Allergy and Clinical Immunology
resource representing a document's body	covid:2f739ce158fe0605ca31cd2b83e00abfba4c6823#body_text
is schema:about of	named entity 'adverse' named entity 'IgE' named entity 'allergens' named entity 'rhinovirus' named entity 'age' named entity 'wheezing' named entity 'age' named entity 'atopic' named entity 'dominant' named entity 'compared' named entity 'Background' named entity 'period' named entity 'atopy' named entity 'SEPTEMBER' named entity 'LOW' named entity 'SEASON' named entity 'LEAD' named entity 'PERCENT' named entity 'CONTROL' named entity 'POSITIVE FOR' named entity 'SERUM' named entity 'HOSPITALIZED' named entity 'MEASURED' named entity 'OVERLAPPED' named entity 'VIRAL' named entity 'HIGHER' named entity 'WHEEZING' named entity 'PATHOGEN' named entity 'SEVENTY' named entity 'OBJECTIVE' named entity 'MARCH' named entity 'TESTS' named entity 'VIRUS' named entity 'YEARS' named entity 'VIRAL INFECTIONS' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'CHARACTERISTICS' named entity 'ADMISSION' named entity 'MONTHS' named entity 'TOTAL' named entity 'BUT' named entity 'PERIOD' named entity 'CONCLUSIONS' named entity 'MAJORITY' named entity 'SPECIFIC IGE ANTIBODY' named entity 'ANTIGEN DETECTION' named entity 'RESPIRATORY TRACT' named entity 'EVALUATE' named entity 'PATIENT' named entity 'ATTACKS' named entity 'ALLERGENS' named entity 'COMPARED' named entity 'CAUSED BY' named entity 'VALUES' named entity 'RHINOVIRUS' named entity 'MEAN' named entity 'WHEEZING' named entity 'VIRGINIA' named entity 'RELATION' named entity 'UNCLEAR' named entity 'DETECTED' named entity 'ABOUT' named entity 'CHILDREN' named entity '27S' named entity 'IGE' named entity 'WAS A' named entity 'AEROALLERGENS' named entity 'VIRAL INFECTIONS' named entity 'ATOPY'

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