About: Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics
Creator	Divita, Gilles Heitz, Frederic Morris, May
Source	Medline; PMC
abstract	The recent discovery of new potent therapeutic molecules that do not reach the clinic due to poor delivery and low bioavailability have made of delivery a key stone in therapeutic development. Several technologies have been designed to improve cellular uptake of therapeutic molecules, including cell-penetrating peptides (CPPs). CPPs were first discovered based on the potency of several proteins to enter cells. Numerous CPPs have been described so far, which can be grouped into two major classes, the first requiring chemical linkage with the drug for cellular internalization and the second involving formation of stable, non-covalent complexes with drugs. Nowadays, CPPs constitute very promising tools for non-invasive cellular import of cargo and have been successfully applied for in vitro and in vivo delivery of therapeutic molecules varying from small chemical molecule, nucleic acids, proteins, peptides, liposomes and particles. This review will focus on the structure/function and cellular uptake mechanism of CPPs in the general context of drug delivery. We will also highlight the application of peptide carriers for the delivery of therapeutic molecules and provide an update of their clinical evaluation. This article is part of a themed section on Vector Design and Drug Delivery. For a list of all articles in this section see the end of this paper, or visit: http://www3.interscience.wiley.com/journal/121548564/issueyear?year=2009
has issue date	2009-03-20(xsd:dateTime)
bibo:doi	10.1111/j.1476-5381.2009.00057.x
bibo:pmid	19309362
has license	green-oa
sha1sum (hex)	2f94d467ffc5aba53260a51d2133fd44bcc42480
schema:url	https://doi.org/10.1111/j.1476-5381.2009.00057.x
resource representing a document's title	Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics
has PubMed Central identifier	PMC2697800
has PubMed identifier	19309362
schema:publication	British Journal of Pharmacology
resource representing a document's body	covid:2f94d467ffc5aba53260a51d2133fd44bcc42480#body_text
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