About: Mechanisms of synergy in polymicrobial infections

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mechanisms of synergy in polymicrobial infections
Creator	Stacy, Apollo Whiteley, Marvin Connell, Jodi Murray, Justine Turner, Keith
Source	PMC
abstract	Communities of microbes can live almost anywhere and contain many different species. Interactions between members of these communities often determine the state of the habitat in which they live. When these habitats include sites on the human body, these interactions can affect health and disease. Polymicrobial synergy can occur during infection, in which the combined effect of two or more microbes on disease is worse than seen with any of the individuals alone. Powerful genomic methods are increasingly used to study microbial communities, including metagenomics to reveal the members and genetic content of a community and metatranscriptomics to describe the activities of community members. Recent efforts focused toward a mechanistic understanding of these interactions have led to a better appreciation of the precise bases of polymicrobial synergy in communities containing bacteria, eukaryotic microbes, and/or viruses. These studies have benefited from advances in the development of in vivo models of polymicrobial infection and modern techniques to profile the spatial and chemical bases of intermicrobial communication. This review describes the breadth of mechanisms microbes use to interact in ways that impact pathogenesis and techniques to study polymicrobial communities.
has issue date	2014-03-01(xsd:dateTime)
bibo:doi	10.1007/s12275-014-4067-3
bibo:pmid	24585050
has license	no-cc
sha1sum (hex)	2f9cd31e8badabf3837a76de010f5b4cda46356c
schema:url	https://doi.org/10.1007/s12275-014-4067-3
resource representing a document's title	Mechanisms of synergy in polymicrobial infections
has PubMed Central identifier	PMC7090983
has PubMed identifier	24585050
schema:publication	J Microbiol
resource representing a document's body	covid:2f9cd31e8badabf3837a76de010f5b4cda46356c#body_text
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