About: Adaptive modeling of viral diseases in bats with a focus on rabies

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Adaptive modeling of viral diseases in bats with a focus on rabies
Creator	Rupprecht, Charles Dimitrov, Dobromir Hallam, Thomas Mccracken, Gary
Source	Elsevier; Medline; PMC
abstract	Abstract Many emerging and reemerging viruses, such as rabies, SARS, Marburg, and Ebola have bat populations as disease reservoirs. Understanding the spillover from bats to humans and other animals, and the associated health risks requires an analysis of the disease dynamics in bat populations. Traditional compartmental epizootic models, which are relatively easy to implement and analyze, usually impose unrealistic aggregation assumptions about disease-related structure and depend on parameters that frequently are not measurable in field conditions. We propose a novel combination of computational and adaptive modeling approaches that address the maintenance of emerging diseases in bat colonies through individual (intra-host) models of the response of the host to a viral challenge. The dynamics of the individual models are used to define survival, susceptibility and transmission conditions relevant to epizootics as well as to develop and parametrize models of the disease evolution into uniform and diverse populations. Applications of the proposed approach to modeling the effects of immunological heterogeneity on the dynamics of bat rabies are presented.
has issue date	2008-11-07(xsd:dateTime)
bibo:doi	10.1016/j.jtbi.2008.08.007
bibo:pmid	18761020
has license	els-covid
sha1sum (hex)	3007489c6714d99d180ce21a212f51bdd9dd709e
schema:url	https://doi.org/10.1016/j.jtbi.2008.08.007
resource representing a document's title	Adaptive modeling of viral diseases in bats with a focus on rabies
has PubMed Central identifier	PMC7126102
has PubMed identifier	18761020
schema:publication	Journal of Theoretical Biology
resource representing a document's body	covid:3007489c6714d99d180ce21a212f51bdd9dd709e#body_text
is schema:about of	named entity 'ADAPTIVE' named entity 'conditions' named entity 'develop' named entity 'rabies' named entity 'individual' named entity 'computational' named entity 'viral' named entity 'structure' named entity 'FOCUS' named entity 'RISKS' named entity 'OTHER ANIMALS' named entity 'USUALLY' named entity 'EVOLUTION' named entity 'ASSOCIATED' named entity 'VIRUSES' named entity 'FIELD' named entity 'EFFECTS' named entity 'BAT' named entity 'APPROACHES' named entity 'RELEVANT' named entity 'POPULATIONS' named entity 'APPROACH' named entity 'COMBINATION' named entity 'TRANSMISSION' named entity 'DIVERSE' named entity 'CHALLENGE' named entity 'CONDITIONS' named entity 'AGGREGATION' named entity 'MAINTENANCE' named entity 'EPIZOOTIC' named entity 'ABOUT' named entity 'UNDERSTANDING' named entity 'APPLICATIONS' named entity 'MEASURABLE' named entity 'IMMUNOLOGICAL' named entity 'PROPOSED' named entity 'UNIFORM' named entity 'BATS' named entity 'RELATED' named entity 'DISEASE RESERVOIRS' named entity 'DEPEND' named entity 'BATS' named entity 'SARS' named entity 'DISEASE' named entity 'EBOLA' named entity 'EPIZOOTICS' named entity 'TRADITIONAL' named entity 'HEALTH' named entity 'VIRAL' named entity 'MODELING' named entity 'USED' named entity 'RABIES' named entity 'RESPONSE' named entity 'DISEASE DYNAMICS' named entity 'STRUCTURE' named entity 'HAVE' named entity 'PARAMETERS' named entity 'VIRAL DISEASES' named entity 'NOVEL' named entity 'ANALYSIS' named entity 'PRESENTED' named entity 'HUMANS' named entity 'FREQUENTLY' named entity 'MODELS' named entity 'DISEASES' named entity 'SUSCEPTIBILITY' named entity 'DYNAMICS' named entity 'COLONIES' named entity 'HOST' named entity 'ADAPTIVE' named entity 'MODELING' named entity 'RABIES' named entity 'SPILLOVER' named entity 'IMPOSE' named entity 'SURVIVAL' named entity 'INDIVIDUAL' named entity 'ADDRESS' named entity 'EASY'

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