About: Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation
Creator	Liu, Jing Liu, Rui Jiang, Kai Agrawal, Madhur Apovian, Caroline Belkina, Anna Bharath, Leena Cui, Licong Deeney, Jude Fleeman, Rebecca Guo, Zhenheng Hasturk, Hatice Hawk, Gregory Kern, Philip Mccambridge, Grace Nicholas, Dequina Nikolajczyk, Barbara Pihl, Riley Proctor, Elizabeth Snyder-Cappione, Jennifer Thompson, Katherine
topic	covid:300f7f565108c506f517e6b14372d4ce94c22eaf#this
Source	Elsevier; Medline; PMC
abstract	Age is a non-modifiable risk factor for the inflammation that underlies age-associated diseases; thus, anti-inflammaging drugs hold promise for increasing health span. Cytokine profiling and bioinformatic analyses showed that Th17 cytokine production differentiates CD4(+) T cells from lean, normoglycemic older and younger subjects, and mimics a diabetes-associated Th17 profile. T cells from older compared to younger subjects also had defects in autophagy and mitochondrial bioenergetics that associate with redox imbalance. Metformin ameliorated the Th17 inflammaging profile by increasing autophagy and improving mitochondrial bioenergetics. By contrast, autophagy-targeting siRNA disrupted redox balance in T cells from young subjects and activated the Th17 profile by activating the Th17 master regulator, STAT3, which in turn bound IL-17A and F promoters. Mitophagy-targeting siRNA failed to activate the Th17 profile. We conclude that metformin improves autophagy and mitochondrial function largely in parallel to ameliorate a newly defined inflammaging profile that echoes inflammation in diabetes.
has issue date	2020-05-12(xsd:dateTime)
bibo:doi	10.1016/j.cmet.2020.04.015
bibo:pmid	32402267
has license	no-cc
sha1sum (hex)	300f7f565108c506f517e6b14372d4ce94c22eaf
schema:url	https://doi.org/10.1016/j.cmet.2020.04.015
resource representing a document's title	Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation
has PubMed Central identifier	PMC7217133
has PubMed identifier	32402267
schema:publication	Cell Metab
resource representing a document's body	covid:300f7f565108c506f517e6b14372d4ce94c22eaf#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/300f7f565108c506f517e6b14372d4ce94c22eaf
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