About: Characteristics of Renal Function in Patients Diagnosed With COVID-19: An Observational Study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Characteristics of Renal Function in Patients Diagnosed With COVID-19: An Observational Study
Creator	Huang, Hong Lin, Hao Chen, Rui-Lie Chi, Ze-Pai Fan, Jing-Ru Guo, Shun-Qi Hong, Xu-Wei Lin, Xian-Wei Liu, Guo-Yuan Pan, Ze-Qun Qu, Liao-Zhun Sarwal, Minnie Wang, Liang-Yu Wu, Ling-Jie Wu, Su-Wu Zhang, Qi-Chuan Zhang, Yong-Hai Zhou, Yu-Hua Hutchens, Michael Liu, Chi Lopez-Andres, Natalia
source	Medline; PMC
abstract	Objective: The aim of the study was to analyze the characteristics of renal function in patients diagnosed with COVID-19. Methods: In this retrospective, single-center study, we included all confirmed cases of COVID-19 in a tertiary hospital in Guangdong, China from January 20, 2020 to March 20, 2020. Blood and urine laboratory findings related to renal function were summarized, and the estimated glomerular filtration rate (eGFR) and endogenous creatinine clearance (Ccr) were also calculated to assess the renal function. Results: A total of 12 admitted hospital patients were diagnosed with COVID-19, included 3 severe cases, and 9 common cases. Serum creatinine (Scr) was not abnormally elevated in all of the patients, and blood urea nitrogen (BUN) was abnormally elevated in only 25.0% of the patients. However, compared with the recovery period, the patient's Scr and BUN increased significantly in peak of disease (p-scr = 0.002 & p-bun < 0.001). By observing the fluctuations in Scr and BUN from admission to recovery, it was found that the peak of Scr and BUN appeared within the first 14 day of the course of the disease. Urinary microprotein detection indicated that the abnormally elevated rates of urine microalbumin (UMA), α1-microglobulin (A1M), urine immunoglobulin-G (IGU), and urine transferring (TRU) standardized by urinary creatinine in peak of disease were 41.7, 41.7, 50.0, and 16.7%, respectively. The abnormal rates of the calculated eGFR and Ccr were 66.7 and 41.7%. Conclusion: Scr and BUN were generally increased during the course of COVID-19. Detection of urinary microproteins and application of multiple indicators assessment could be helpful for discovering abnormal renal function in patients with COVID-19. However, the evidence is limited due to the small sample size and observational nature. Additional studies, especially large prospective cohort studies, are required to confirm these findings.
has issue date	2020-07-10(xsd:dateTime)
bibo:doi	10.3389/fmed.2020.00409
bibo:pmid	32754610
has license	cc-by
sha1sum (hex)	301265bd92ae25701c5171f5fddfd7a08556dcc8
schema:url	https://doi.org/10.3389/fmed.2020.00409
resource representing a document's title	Characteristics of Renal Function in Patients Diagnosed With COVID-19: An Observational Study
has PubMed Central identifier	PMC7365839
has PubMed identifier	32754610
schema:publication	Front Med (Lausanne)
resource representing a document's body	covid:301265bd92ae25701c5171f5fddfd7a08556dcc8#body_text
is schema:about of	named entity 'URINE' named entity 'CREATININE CLEARANCE' named entity 'FINDINGS' named entity 'RELATED' covid:arg/301265bd92ae25701c5171f5fddfd7a08556dcc8 named entity 'estimated glomerular filtration rate' named entity 'creatinine clearance' named entity 'COVID-19' named entity 'Observational Study' named entity 'Computed tomography' named entity 'COVID' named entity 'Kim-1' named entity 'renal tubular' named entity 'World Health Organization' named entity 'esophagus' named entity 'Middle East respiratory syndrome coronavirus' named entity 'hypoproteinemia' named entity 'COVID-19' named entity 'diabetes' named entity 'clinical evidence' named entity '2019-nCoV' named entity 'fever' named entity 'Wuhan' named entity 'uremia' named entity 'COVID-19' named entity 'microprotein' named entity 'eGFR' named entity 'tested positive' named entity 'adversely affect' named entity 'creatinine clearance' named entity 'Urine' named entity 'cough' named entity 'spread of disease' named entity 'urine' named entity 'P-value' named entity 'liver' named entity 'myalgia' named entity 'COVID-19' named entity 'Guangdong' named entity 'virus' named entity 'diarrhea' named entity 'C-reactive protein' named entity 'acid-base balance' named entity 'coronavirus' named entity 'sore throat' named entity 'biomarkers' named entity 'China' named entity 'renal reabsorption' named entity '2019-nCoV' named entity 'UCr' named entity 'ileum' named entity 'excretion' named entity 'microprotein' named entity 'eGFR' named entity 'COVID-19' named entity 'neutrophil' named entity 'kidney' named entity 'coagulation' named entity 'pneumonia' named entity 'pneumonia' named entity 'urine creatinine'

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