About: Oral Vaccination with the Porcine Rotavirus VP4 Outer Capsid Protein Expressed by Lactococcus lactis Induces Specific Antibody Production

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About: Oral Vaccination with the Porcine Rotavirus VP4 Outer Capsid Protein Expressed by Lactococcus lactis Induces Specific Antibody Production Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Oral Vaccination with the Porcine Rotavirus VP4 Outer Capsid Protein Expressed by Lactococcus lactis Induces Specific Antibody Production
Creator	Liu, Min Ge, Jun-Wei Li, Gui-Wei Li, Yi-Jing Liu, Li-Wei Ma, Guang-Peng Qiao, Xin-Yuan Tang, Li-Jie
Source	Medline; PMC
abstract	The objective of this study to design a delivery system resistant to the gastrointestinal environment for oral vaccine against porcine rotavirus. Lactococcus lactis NZ9000 was transformed with segments of vP4 of the porcine rotavirus inserted into the pNZ8112 surface-expression vector, and a recombinant L. lactis expressing VP4 protein was constructed. An approximately 27 kDa VP4 protein was confirmed by SDS-PAGE , Western blot and immunostaining analysis. BALB/c mice were immunized orally with VP4-expression recombinant L. lactis and cellular, mucosal and systemic humoral immune responses were examined. Specific anti-VP4 secretory IgA and IgG were found in feces, ophthalmic and vaginal washes and in serum. The induced antibodies demonstrated neutralizing effects on porcine rotavirus infection on MA104 cells. Our findings suggest that oral immunization with VP4-expressing L. lactis induced both specific local and systemic humoral and cellular immune responses in mice.
has issue date	2010-06-06(xsd:dateTime)
bibo:doi	10.1155/2010/708460
bibo:pmid	20625406
has license	no-cc
sha1sum (hex)	30175004a6a58f006a53f32c00e0363c126f667b
schema:url	https://doi.org/10.1155/2010/708460
resource representing a document's title	Oral Vaccination with the Porcine Rotavirus VP4 Outer Capsid Protein Expressed by Lactococcus lactis Induces Specific Antibody Production
has PubMed Central identifier	PMC2896853
has PubMed identifier	20625406
schema:publication	J Biomed Biotechnol
resource representing a document's body	covid:30175004a6a58f006a53f32c00e0363c126f667b#body_text
is schema:about of	named entity 'EXPRESSED' named entity 'ANTIBODY PRODUCTION' named entity 'resistant' named entity 'vaccine' named entity 'feces' named entity 'IgA' named entity 'induced' named entity 'protein' named entity 'L. lactis' named entity 'effects' named entity 'LACTOCOCCUS LACTIS' named entity 'FINDINGS' named entity 'SPECIFIC' named entity 'INDUCED' named entity 'EXPRESSION VECTOR' named entity 'STUDY' named entity 'ROTAVIRUS INFECTION' named entity 'KDA' named entity 'ENVIRONMENT' named entity 'WESTERN BLOT' named entity 'ORALLY' named entity 'MUCOSAL' named entity 'VP4 PROTEIN' named entity 'FOUND' named entity 'LACTOCOCCUS LACTIS' named entity 'IGG' named entity 'CONFIRMED BY' named entity 'SERUM' named entity 'PORCINE ROTAVIRUS' named entity 'ORAL IMMUNIZATION' named entity 'OUR' named entity 'SDS-PAGE' named entity 'ANTIBODIES' named entity 'SYSTEMIC' named entity 'DEMONSTRATED' named entity 'APPROXIMATELY' named entity 'EXAMINED' named entity 'PORCINE ROTAVIRUS' named entity 'LOCAL' named entity 'MICE' named entity 'IMMUNOSTAINING' named entity 'CONSTRUCTED' named entity 'IMMUNIZED' named entity 'ANALYSIS' named entity 'ORAL VACCINE' named entity 'OUTER CAPSID' named entity 'CAPSID PROTEIN' named entity 'VP4' named entity 'SPECIFIC ANTIBODY' named entity 'BALB' named entity 'CELLULAR' named entity 'PROTEIN ' named entity 'VAGINAL' named entity 'GASTROINTESTINAL' named entity 'MA104' named entity 'RECOMBINANT' named entity 'FECES' named entity 'CELLS' named entity 'RESISTANT TO' named entity 'SURFACE' named entity 'IMMUNE RESPONSES' named entity 'DELIVERY SYSTEM' named entity 'SUGGEST' named entity 'PROTEIN ' named entity 'ORAL VACCINATION' named entity 'EXPRESSION' named entity 'SEGMENTS' named entity 'VP4' named entity 'TRANSFORMED' named entity 'INSERTED INTO' named entity 'OBJECTIVE' named entity 'SECRETORY IGA' named entity 'EFFECTS' named entity 'OPHTHALMIC'

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