About: Effects of hypervariable regions in spike protein on pathogenicity, tropism, and serotypes of infectious bronchitis virus

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About: Effects of hypervariable regions in spike protein on pathogenicity, tropism, and serotypes of infectious bronchitis virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Effects of hypervariable regions in spike protein on pathogenicity, tropism, and serotypes of infectious bronchitis virus
Creator	Han, Zongxi Liu, Shengwang Chen, Yuqiu Zhao, Wenjun Jiang, Lei Fang, Shouguo Ai, Hui Shan, Dan
Source	Elsevier; Medline; PMC
abstract	Abstract To study the roles of hypervariable regions (HVRs) in receptor-binding subunit S1 of the spike protein, we manipulated the genome of the IBV Beaudette strain using a reverse genetics system to construct seven recombinant strains by separately or simultaneously replacing the three HVRs of the Beaudette strain with the corresponding fragments from a QX-like nephropathogenic isolate ck/CH/LDL/091022 from China. We characterized the growth properties of these recombinant IBVs in Vero cells and embryonated eggs, and their pathogenicity, tropism, and serotypes in specific pathogen-free (SPF) chickens. All seven recombinant IBVs proliferated in Vero cells, but the heterogenous HVRs could reduce their capacity for adsorption during in vitro infection. The recombinant IBVs did not significantly increase the pathogenicity compared with the Beaudette strain in SPF chickens, and they still shared the same serotype as the Beaudette strain, but the antigenic relatedness values between the recombinant strain and Beaudette strain generally decreased with the increase in the number of the HVRs exchanged. The results of this study demonstrate the functions of HVRs and they may help to develop a vaccine candidate, as well as providing insights into the prevention and control of IBV.
has issue date	2018-05-02(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2018.04.013
bibo:pmid	29684409
has license	els-covid
sha1sum (hex)	305de00f1d5d6a77a540fe93d04da1b5921d7785
schema:url	https://doi.org/10.1016/j.virusres.2018.04.013
resource representing a document's title	Effects of hypervariable regions in spike protein on pathogenicity, tropism, and serotypes of infectious bronchitis virus
has PubMed Central identifier	PMC7114591
has PubMed identifier	29684409
schema:publication	Virus Research
resource representing a document's body	covid:305de00f1d5d6a77a540fe93d04da1b5921d7785#body_text
is schema:about of	named entity 'FREE' named entity 'USING' named entity 'ADSORPTION' named entity 'GROWTH' named entity 'PROPERTIES' named entity 'SPIKE PROTEIN' named entity 'VERO CELLS' named entity 'PATHOGENICITY' named entity 'FRAGMENTS' named entity 'ROLES' named entity 'STRAINS' named entity 'CAPACITY' named entity 'GENERALLY' named entity 'VACCINE CANDIDATE' named entity 'HELP' named entity 'IBV' named entity 'RECEPTOR' named entity 'INCREASE' named entity 'develop' named entity 'system' named entity 'construct' named entity 'China' named entity 'manipulated' named entity 'serotypes' named entity 'spike' named entity 'generally' named entity 'Vero' named entity 'virus' named entity 'HETEROGENOUS' named entity 'SYSTEM' named entity 'PROTEIN ' named entity 'INSIGHTS' named entity 'FUNCTIONS' named entity 'EXCHANGED' named entity 'ISOLATE' named entity 'SEROTYPE' named entity 'STUDY' named entity 'REDUCE' named entity 'REVERSE GENETICS' named entity 'PATHOGEN' named entity 'BUT' named entity 'SIMULTANEOUSLY' named entity 'PROVIDING' named entity 'CHARACTERIZED' named entity 'SPIKE PROTEIN' named entity 'SEROTYPES' named entity 'TROPISM' named entity 'PATHOGENICITY' named entity 'EFFECTS' named entity 'RECOMBINANT' named entity 'COMPARED' named entity 'IN VITRO' named entity 'SHARED' named entity 'THEIR' named entity 'SUBUNIT' named entity 'VALUES' named entity 'SEROTYPES' named entity 'BINDING' named entity 'EGGS' named entity 'SPECIFIC' named entity 'SPF' named entity 'LIKE' named entity 'DID' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'REGIONS' named entity 'DECREASED' named entity 'RESULTS' named entity 'NUMBER OF' named entity 'REPLACING' named entity 'CHICKENS' named entity 'CONSTRUCT' named entity 'STRAIN' named entity 'THESE' named entity 'PREVENTION AND CONTROL'

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