About: Oral immunization of a non-recombinant Lactococcus lactis surface displaying influenza hemagglutinin 1 (HA1) induces mucosal immunity in mice

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About: Oral immunization of a non-recombinant Lactococcus lactis surface displaying influenza hemagglutinin 1 (HA1) induces mucosal immunity in mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Oral immunization of a non-recombinant Lactococcus lactis surface displaying influenza hemagglutinin 1 (HA1) induces mucosal immunity in mice
Creator	Chang, Li-Yen Jee, Pui-Fong Khoo, Jing-Jing Shu, Meng-Hooi Tiong, Vunjia Abubakar, Sazaly Rahim, Raha Wong, Won
source	PMC
abstract	Mucosal immunization of influenza vaccine is potentially an effective approach for the prevention and control of influenza. The objective of the present study was to evaluate the ability of oral immunization with a non-recombinant Lactococcus lactis displaying HA1/L/AcmA recombinant protein, LL-HA1/L/AcmA, to induce mucosal immune responses and to accord protection against influenza virus infection in mice. The LL-HA1/L/AcmA was orally administered into mice and the immune response was evaluated. Mice immunized with LL-HA1/L/AcmA developed detectable specific sIgA in faecal extract, small intestine wash, BAL fluid and nasal fluid. The results obtained demonstrated that oral immunization of mice with LL-HA1/L/AcmA elicited mucosal immunity in both the gastrointestinal tract and the respiratory tract. The protective efficacy of LL-HA1/L/AcmA in immunized mice against a lethal dose challenge with influenza virus was also assessed. Upon challenge, the non-immunized group of mice showed high susceptibility to influenza virus infection. In contrast, 7/8 of mice orally immunized with LL-HA1/L/AcmA survived. In conclusion, oral administration of LL-HA1/L/AcmA in mice induced mucosal immunity and most importantly, provided protection against lethal influenza virus challenge. These results highlight the potential application of L. lactis as a platform for delivery of influenza virus vaccine.
has issue date	2017-11-06(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0187718
bibo:pmid	29108012
has license	cc-by
sha1sum (hex)	306c2b4690eb9e399d2f301c7ca36eca27cad013
schema:url	https://doi.org/10.1371/journal.pone.0187718
resource representing a document's title	Oral immunization of a non-recombinant Lactococcus lactis surface displaying influenza hemagglutinin 1 (HA1) induces mucosal immunity in mice
has PubMed Central identifier	PMC5673223
has PubMed identifier	29108012
schema:publication	PLoS One
resource representing a document's body	covid:306c2b4690eb9e399d2f301c7ca36eca27cad013#body_text
is schema:about of	named entity 'DISPLAYING' named entity 'virus' named entity 'mice' named entity 'control' named entity 'ACCESS' named entity 'hemagglutinin' named entity 'CONTRAST' named entity 'OBTAINED' named entity 'ACCESS' named entity 'HIGH' named entity 'IMMUNE RESPONSES' named entity 'RECOMBINANT PROTEIN' named entity 'CONCLUSION' named entity 'EFFECTIVE' named entity 'FAECAL' named entity 'ASSESSED' named entity 'SIGA' named entity 'POTENTIAL' named entity 'WONG' named entity 'RESULTS' named entity 'ELICITED' named entity 'GASTROINTESTINAL TRACT' named entity 'CHALLENGE' named entity 'DELIVERY' named entity 'RECOMBINANT' named entity 'APPLICATION' named entity 'PRESENT' named entity 'INFLUENZA HEMAGGLUTININ' named entity '2F10' named entity 'DETECTABLE' named entity 'APPROACH' named entity 'ORALLY' named entity 'OBJECTIVE' named entity 'ORG' named entity 'HTTPS' named entity 'DEMONSTRATED' named entity 'INFLUENZA VACCINE' named entity 'INDUCE' named entity 'PROTECTION' named entity 'RESPIRATORY TRACT' named entity 'LACTOCOCCUS LACTIS' named entity 'OPEN' named entity 'SHU' named entity 'ORAL ADMINISTRATION' named entity 'ABILITY' named entity 'NON-' named entity 'WASH' named entity 'ORAL IMMUNIZATION' named entity 'MUCOSAL IMMUNIZATION' named entity 'LACTOCOCCUS LACTIS' named entity 'INFLUENZA VIRUS' named entity 'VIRUS INFECTION' named entity 'ORAL IMMUNIZATION' named entity 'NON-' named entity 'RECOMBINANT' named entity 'INFLUENZA HEMAGGLUTININ' named entity 'SURFACE' named entity 'MICE' named entity 'MICE' named entity 'FLUID' named entity 'THESE' named entity 'EFFICACY' named entity 'BAL' named entity 'PREVENTION AND CONTROL' named entity 'NASAL FLUID' named entity 'INFLUENZA VIRUS VACCINE' named entity 'EXTRACT' named entity 'STUDY' named entity 'SURFACE' named entity 'INDUCED' named entity 'GROUP' named entity 'IMMUNE RESPONSE' named entity 'PLATFORM' named entity 'EVALUATE'

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