About: Polyphenol-Rich Extracts from Toona sinensis Bark and Fruit Ameliorate Free Fatty Acid-Induced Lipogenesis through AMPK and LC3 Pathways

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About: Polyphenol-Rich Extracts from Toona sinensis Bark and Fruit Ameliorate Free Fatty Acid-Induced Lipogenesis through AMPK and LC3 Pathways Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Polyphenol-Rich Extracts from Toona sinensis Bark and Fruit Ameliorate Free Fatty Acid-Induced Lipogenesis through AMPK and LC3 Pathways
Creator	Chen, Yu-Chi Chang, Chi-Fen Chen, Hsin-Ju Chen, Yung-Chia Huang, Bu-Miin
topic	covid:30793ddad13205696658bbb0a2083c1cd400aab7#this
Source	PMC
abstract	Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease found worldwide. The present study aimed to evaluate the mechanisms of inhibiting lipid accumulation in free fatty acid (FFA)-treated HepG2 cells caused by bark and fruit extracts of Toona sinensis (TSB and TSF). FFA induced lipid and triglyceride (TG) accumulation, which was attenuated by TSB and TSF. TSB and/or TSF promoted phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-coA carboxylase and peroxisome proliferator-activated receptor alpha upregulation. Furthermore, TSB and TSF suppressed FFA-induced liver X receptor, sterol regulatory element-binding transcription protein 1, fatty acid synthase, and stearoyl-CoA desaturase 1 protein expression. Moreover, TSB and/or TSF induced phosphorylation of Unc-51 like autophagy-activating kinase and microtubule-associated protein 1A/1B-light chain 3 expressions. Therefore, TSB and TSF relieve lipid accumulation by attenuating lipogenic protein expression, activating the AMPK pathway, and upregulating the autophagic flux to enhance lipid metabolism. Moreover, TSB and TSF reduced TG contents, implying the therapeutic use of TSB and TSF in NAFLD.
has issue date	2019-10-11(xsd:dateTime)
bibo:doi	10.3390/jcm8101664
bibo:pmid	31614650
has license	cc-by
sha1sum (hex)	30793ddad13205696658bbb0a2083c1cd400aab7
schema:url	https://doi.org/10.3390/jcm8101664
resource representing a document's title	Polyphenol-Rich Extracts from Toona sinensis Bark and Fruit Ameliorate Free Fatty Acid-Induced Lipogenesis through AMPK and LC3 Pathways
has PubMed Central identifier	PMC6832244
has PubMed identifier	31614650
schema:publication	J Clin Med
resource representing a document's body	covid:30793ddad13205696658bbb0a2083c1cd400aab7#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/30793ddad13205696658bbb0a2083c1cd400aab7
is schema:about of	named entity 'lipid' named entity 'attenuated' named entity 'NAFLD' named entity 'attenuating' named entity 'TOONA SINENSIS' covid:arg/30793ddad13205696658bbb0a2083c1cd400aab7 named entity 'PATHWAYS' named entity 'CLINICAL MEDICINE' named entity 'FREE FATTY ACID' named entity 'LIKE' named entity 'BINDING PROTEIN' named entity 'CAUSED BY' named entity 'LIPID ACCUMULATION' named entity 'SUPPRESSED' named entity 'USE OF' named entity 'AMP-ACTIVATED PROTEIN KINASE' named entity 'UPREGULATION' named entity 'RESPONSE ELEMENT' named entity 'FRUIT EXTRACTS' named entity 'AUTOPHAGY' named entity 'LIPOGENIC' named entity 'BARK' named entity 'PROTEIN EXPRESSION' named entity 'NAFLD' named entity 'PATHWAY' named entity 'MECHANISMS' named entity 'FREE FATTY ACID' named entity 'PHOSPHORYLATION' named entity 'STEAROYL-COA DESATURASE 1' named entity 'WORLDWIDE' named entity 'LIPID' named entity 'LIGHT CHAIN' named entity 'TREATED' named entity 'PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA' named entity 'TOONA SINENSIS' named entity 'STEROL' named entity 'TSF' named entity 'FATTY ACID SYNTHASE' named entity 'TRANSPORT PROTEINS' named entity 'CONTENTS' named entity 'LIPID SYNTHESIS' named entity 'INHIBITING' named entity 'BARK' named entity 'FRUIT' named entity 'LIPOGENESIS' named entity 'AMPK' named entity 'CARBOHYDRATE' named entity 'FFA' named entity 'EXPRESSIONS' named entity 'PROMOTING' named entity 'PRESENT' named entity 'SPECIFIC' named entity 'ACETYL-COA CARBOXYLASE' named entity 'OXIDATION' named entity 'THERAPEUTIC USE' named entity 'RELIEVE' named entity 'EVALUATE' named entity 'FOUND' named entity 'LIVER X RECEPTOR' named entity 'RICH' named entity 'POLYPHENOL' named entity 'INDUCED' named entity 'EXTRACTS' named entity 'AMPK' named entity 'ATTENUATED BY' named entity 'REGULATORY ELEMENT' named entity 'KINASE' named entity 'INDUCED' named entity 'TRIGLYCERIDE' named entity 'LIPID METABOLISM' named entity 'IS A' named entity 'ACCUMULATION' named entity 'DE NOVO' named entity 'BINDING' named entity 'REDUCED'

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