About: Role for Maternal Asthma in Severe Human Metapneumovirus Lung Disease Susceptibility in Children

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Role for Maternal Asthma in Severe Human Metapneumovirus Lung Disease Susceptibility in Children
Creator	Polack, Fernando Acosta, Patricio Bergel, Eduardo Bianchi, Alejandra Caballero, Mauricio Dueñas, Karina Esteban, Ignacio Ferolla, Fausto Ferrero, Fernando Grimaldi, Luciano Libster, Romina Rodriguez, Andrea Sancillo, Andrea Stein, Katherine
source	Medline; PMC
abstract	BACKGROUND: Severity of human metapneumovirus (hMPV) lower respiratory illness (LRTI) is considered similar to that observed for respiratory syncytial virus (RSV). However, differences in severity between these pathogens have been noted, suggesting the degree of illness may vary in different populations. Moreover, a potential association between hMPV and asthma also suggests that hMPV may preferentially affect asthmatic subjects. METHODS: In a population-based surveillance study in children aged <2 years admitted for severe LRTI in Argentina, nasopharyngeal aspirates were tested by RT-PCR for hMPV, RSV, influenza A, and human rhinovirus. RESULTS: Of 3947 children, 383 (10%) were infected with hMPV. The hospitalization rate for hMPV LRTI was 2.26 per 1000 children (95% confidence interval [CI], 2.04–2.49). Thirty-nine (10.2%) patients infected with hMPV experienced life-threatening disease (LTD; 0.23 per 1000 children; 95% CI, .16–.31/1000), and 2 died (mortality rate 0.024 per 1000; 95% CI, .003–.086). In hMPV-infected children birth to an asthmatic mother was an increased risk for LTD (odds ratio, 4.72; 95% CI, 1.39–16.01). We observed a specific interaction between maternal asthma and hMPV infection affecting risk for LTD. CONCLUSIONS: Maternal asthma increases the risk for LTD in children <2 years old hospitalized for severe hMPV LRTI.
has issue date	2020-01-22(xsd:dateTime)
bibo:doi	10.1093/infdis/jiaa019
bibo:pmid	31965186
has license	cc-by
sha1sum (hex)	3082305a8cb52e0b436ed787d30a75f17f1fd838
schema:url	https://doi.org/10.1093/infdis/jiaa019
resource representing a document's title	Role for Maternal Asthma in Severe Human Metapneumovirus Lung Disease Susceptibility in Children
has PubMed Central identifier	PMC7107446
has PubMed identifier	31965186
schema:publication	J Infect Dis
resource representing a document's body	covid:3082305a8cb52e0b436ed787d30a75f17f1fd838#body_text
is schema:about of	named entity 'asthmatic' named entity 'However' named entity 'Susceptibility' named entity 'Asthma' named entity 'LUNG DISEASE' named entity 'ROLE' named entity 'CHILDREN' named entity 'INFECTIOUS DISEASES' named entity 'ASTHMA' named entity 'POTENTIAL' named entity 'NOTED' named entity 'DEGREE' named entity 'PATHOGENS' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'JOURNAL ' named entity 'SEVERE' named entity 'HUMAN METAPNEUMOVIRUS' named entity 'DISEASE SUSCEPTIBILITY' named entity 'LOWER' named entity 'RESPIRATORY ILLNESS' named entity 'OBSERVED' named entity 'HAVE' named entity 'ILLNESS' named entity 'ASSOCIATION' named entity 'AFFECT' named entity 'HUMAN METAPNEUMOVIRUS' named entity 'BACKGROUND' named entity 'THESE' named entity 'MATERNAL ASTHMA' named entity 'POPULATIONS' named entity 'ASTHMATIC' named entity 'SIMILAR' named entity 'SUBJECTS' named entity 'DIFFERENT' named entity 'SEVERITY' named entity 'CONSIDERED' covid:arg/3082305a8cb52e0b436ed787d30a75f17f1fd838 named entity 'respiratory syncytial virus' named entity 'populations' named entity 'asthmatic' named entity 'pathogens' named entity 'respiratory syncytial virus' named entity 'asthma' named entity 'Human Metapneumovirus' named entity '95% CI' named entity 'young children' named entity 'logistic regression' named entity 'LTD' named entity 'hMPV' named entity '95% CI' named entity 'univariate analysis' named entity 'disease burden' named entity 'virus' named entity 'perinatal' named entity 'hMPV' named entity 'viruses' named entity 'inflammation' named entity 'clinical signs' named entity 'IL-13' named entity 'asthmatic' named entity 'eosinophilic' named entity '95% CI' named entity 'logistic regression' named entity 'hMPV' named entity 'asthmatic' named entity 'pathogen' named entity 'asthmatic' named entity 'RSV'

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