About: Inhibitors of c-Jun N-terminal kinases

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About: Inhibitors of c-Jun N-terminal kinases—JuNK no more? Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Inhibitors of c-Jun N-terminal kinases—JuNK no more?
Creator	Arthur, Peter Bogoyevitch, Marie
Source	Elsevier; Medline; PMC
abstract	Abstract The c-Jun N-terminal kinases (JNKs) have been the subject of intense interest since their discovery in the early 1990s. Major research programs have been directed to the screening and/or design of JNK-selective inhibitors and testing their potential as drugs. We begin this review by considering the first commercially-available JNK ATP-competitive inhibitor, SP600125. We focus on recent studies that have evaluated the actions of SP600125 in lung, brain, kidney and liver following exposure to a range of stress insults including ischemia/reperfusion. In many but not all cases, SP600125 administration has proved beneficial. JNK activation can also follow infection, and we next consider recent examples that demonstrate the benefits of SP600125 administration in viral infection. Additional ATP-competitive JNK inhibitors have now been described following high throughput screening of small molecule libraries, but information on their use in biological systems remains limited and thus these inhibitors will require further evaluation. Peptide substrate-competitive ATP-non-competitive inhibitors of JNK have also now been described, and we discuss the recent advances in the use of JNK inhibitory peptides in the treatment of neuronal death, diabetes and viral infection. We conclude by raising a number of questions that should be considered in the quest for JNK-specific inhibitors.
has issue date	2008-01-31(xsd:dateTime)
bibo:doi	10.1016/j.bbapap.2007.09.013
bibo:pmid	17964301
has license	els-covid
sha1sum (hex)	30f527ca58ab6bff727209999d7eeaabd5dd51fc
schema:url	https://doi.org/10.1016/j.bbapap.2007.09.013
resource representing a document's title	Inhibitors of c-Jun N-terminal kinases—JuNK no more?
has PubMed Central identifier	PMC7185448
has PubMed identifier	17964301
schema:publication	Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
resource representing a document's body	covid:30f527ca58ab6bff727209999d7eeaabd5dd51fc#body_text
is schema:about of	named entity 'INHIBITORY' named entity 'CASES' named entity 'COMPETITIVE' named entity 'SUBJECT' named entity 'INCLUDING' named entity 'N-TERMINAL ' named entity 'RESEARCH' named entity 'INFECTION' named entity 'ADMINISTRATION' named entity 'FOLLOW' named entity 'SUBSTRATE' named entity 'CONSIDER' named entity 'DISCOVERY' named entity 'stress' named entity 'JNK' named entity 'Inhibitors' named entity 'JUNK' covid:arg/30f527ca58ab6bff727209999d7eeaabd5dd51fc named entity 'STUDIES' named entity 'EARLY' named entity 'INTENSE' named entity 'JNK ACTIVATION' named entity 'BIOLOGICAL' named entity 'SCREENING' named entity 'INHIBITORS' named entity 'KINASES' named entity 'C-JUN' named entity 'N-TERMINAL ' named entity 'STRESS' named entity 'FOLLOWING' named entity 'SELECTIVE' named entity 'QUEST' named entity 'NUMBER OF' named entity 'C-JUN' named entity 'VIRAL INFECTION' named entity 'LIVER' named entity 'DRUGS' named entity 'RANGE' named entity 'BRAIN' named entity 'PEPTIDES' named entity 'DIRECTED' named entity 'AVAILABLE' named entity 'INHIBITORS' named entity 'DESCRIBED' named entity 'PROGRAMS' named entity 'ADDITIONAL' named entity 'BEGIN' named entity 'ISCHEMIA' named entity 'TESTING' named entity 'SMALL MOLECULE LIBRARIES' named entity 'CONSIDERING' named entity 'JNK' named entity 'LIMITED' named entity 'MAJOR' named entity 'FOCUS' named entity 'HIGH THROUGHPUT SCREENING' named entity 'THESE' named entity 'LUNG' named entity 'BENEFICIAL' named entity 'HAVE' named entity 'PEPTIDE' named entity 'DIABETES' named entity 'DESIGN' named entity 'BUT' named entity 'INFORMATION' named entity 'DISCUSS' named entity 'KIDNEY' named entity 'COMPETITIVE INHIBITORS' named entity 'SPECIFIC' named entity 'INTEREST' named entity 'USE OF' named entity 'THEIR' named entity 'USE' named entity 'CONCLUDE' named entity 'SYSTEMS' named entity 'EVALUATION' named entity 'BENEFITS' named entity 'EVALUATED' named entity 'RECENT' named entity 'JNK INHIBITORS'

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