About: CD206(+) tumor-associated macrophages promote proliferation and invasion in oral squamous cell carcinoma via EGF production

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About: CD206(+) tumor-associated macrophages promote proliferation and invasion in oral squamous cell carcinoma via EGF production Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	CD206(+) tumor-associated macrophages promote proliferation and invasion in oral squamous cell carcinoma via EGF production
Creator	Hayashida, Jun-Nosuke Ishiguro, Noriko Kawano, Shintaro Kiyoshima, Tamotsu Kubota, Keigo Maehara, Takashi Moriyama, Masafumi Nakamura, Seiji Sakamoto, Mizuki Tanaka, Akihiko Chinju, Akira Kaneko, Naoki Mochizuki, Keita Munemura, Ryusuke Haque, A
Source	PMC
abstract	Tumor-associated macrophages (TAMs) promote tumor progression and inhibit anti-tumor immune response by producing various mediators and preferentially express CD163, CD204, and CD206. However, the role of these TAM subsets in oral squamous cell carcinoma (OSCC) remains unclear. Here we investigated the expression and function of TAM subsets in OSCC, especially in cancer cell proliferation. Biopsy sample from 44 patients with OSCC were examined for the expression of TAM markers and EGF by immunohistochemistry. EGF production of TAM subsets isolated from OSCC patients was assessed by flow cytometry. We also examined the effect of conditioned medium from TAM subsets on the proliferation of OSCC cells. CD163(+) cells were detected diffusely all over the tumor and connective tissue area, while CD204(+) and CD206(+) cells were mainly detected in/around the tumors. Flow cytometric analysis found that CD206(+) TAMs strongly produced EGF compared with CD163(+) and CD204(+) TAMs. Cell proliferation and invasion of OSCC cells cultured with conditioned medium of CD206(+) TAMs were strongly enhanced and inhibited by anti-EGFR. The number of CD206(+) TAMs positively correlated with worse clinical prognosis. Our results revealed differences in localization and EGF production among these TAM subsets. CD206(+) TAMs might play a critical role in the proliferation of OSCC via EGF production.
has issue date	2019-10-10(xsd:dateTime)
bibo:doi	10.1038/s41598-019-51149-1
bibo:pmid	31601953
has license	cc-by
sha1sum (hex)	310c97d16197e1ab6ff3227b706bed41f079b8ae
schema:url	https://doi.org/10.1038/s41598-019-51149-1
resource representing a document's title	CD206(+) tumor-associated macrophages promote proliferation and invasion in oral squamous cell carcinoma via EGF production
has PubMed Central identifier	PMC6787225
has PubMed identifier	31601953
schema:publication	Sci Rep
resource representing a document's body	covid:310c97d16197e1ab6ff3227b706bed41f079b8ae#body_text
is schema:about of	named entity 'PROMOTE' named entity 'INVASION' named entity 'Flow cytometric' named entity 'patients' named entity 'enhanced' named entity 'TAMs' named entity 'CD163' named entity 'EGF' named entity 'TAM' named entity 'REMAINS' named entity 'PROLIFERATION' named entity 'MACROPHAGES' named entity 'TUMOR' named entity 'CELLS CULTURED' named entity 'PROLIFERATION' covid:arg/310c97d16197e1ab6ff3227b706bed41f079b8ae named entity 'ASSOCIATED' named entity 'CONDITIONED MEDIUM' named entity 'REVEALED' named entity 'EXAMINED' named entity 'CD206' named entity 'POSITIVELY CORRELATED' named entity 'OUR' named entity 'BIOPSY SAMPLE' named entity 'CELL PROLIFERATION' named entity 'ENHANCED' named entity 'ORAL SQUAMOUS CELL CARCINOMA' named entity 'PLAY' named entity 'ANTI-EGFR' named entity 'INVESTIGATED' named entity 'DETECTED' named entity 'EFFECT' named entity 'LOCALIZATION' named entity 'FLOW CYTOMETRY' named entity 'CD163' named entity 'AREA' named entity 'EGF' named entity 'PRODUCTION' named entity 'EGF' named entity 'WORSE' named entity 'UNCLEAR' named entity 'EXPRESSION' named entity 'THESE' named entity 'CD206' named entity 'FOUND' named entity 'EXAMINED FOR' named entity 'CANCER CELL' named entity 'ASSESSED' named entity 'RESULTS' named entity 'MARKERS' named entity 'COMPARED' named entity 'CONNECTIVE TISSUE' named entity 'FUNCTION' named entity 'PRODUCTION' named entity 'PATIENTS' named entity 'NUMBER OF' named entity 'IMMUNOHISTOCHEMISTRY' named entity 'OSCC' named entity 'HERE' named entity 'TUMOR' named entity 'PROGNOSIS' named entity 'TAM' named entity 'CRITICAL' named entity 'CELLS' named entity 'CD204' named entity 'ISOLATED' named entity 'ORAL SQUAMOUS CELL CARCINOMA'

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