About: Enhancement of encephalomyeloradiculitis in mice sensitized with spinal cord tissue and infected with lactate dehydrogenase-elevating virus()

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About: Enhancement of encephalomyeloradiculitis in mice sensitized with spinal cord tissue and infected with lactate dehydrogenase-elevating virus() Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Enhancement of encephalomyeloradiculitis in mice sensitized with spinal cord tissue and infected with lactate dehydrogenase-elevating virus()
Creator	Brinton, Margo Stroop, William
Source	PMC
abstract	C57BR/cdJ mice develop encephalomyeloradiculitis following peripheral inoculation of the C strain of lactate dehydrogenase-elevating virus (LDV-C). We investigated the effect of subcutaneous administration of syngeneic spinal cord homogenate mixed with phosphate buffered saline or emulsified in complete or incomplete Freund's adjuvant 1 week before or after inoculation of LDV-C on the incidence and severity of central nervous system lesions. C57BR/cdJ mice developed an acute histological allergic encephalomyelitis when given 2 weekly sensitizing injections of homogenate in complete Freund's adjuvant. When peripheral inoculation of LDV-C was substituted for one of the two sensitizing injections, a higher percentage of mice developed lesions, and the lesions were more severe and persisted for much longer periods of time. This same lesion-enhancing effect was not observed if the mice were sensitized with homogenate suspended in buffer or emulsified in incomplete Freund's adjuvant. Interestingly, mice sensitized with complete Freund's adjuvant alone before or after infection with LDV-C also developed intense central nervous system lesions, suggesting that the mycobacterial component of the adjuvant was the critical element in enhancing the lesions.
has issue date	2005-06-03(xsd:dateTime)
bibo:doi	10.1016/s0165-5728(85)80049-7
bibo:pmid	3998124
has license	no-cc
sha1sum (hex)	313d267468273358ccb89b3df7091e2b788b27cf
schema:url	https://doi.org/10.1016/s0165-5728%2885%2980049-7
resource representing a document's title	Enhancement of encephalomyeloradiculitis in mice sensitized with spinal cord tissue and infected with lactate dehydrogenase-elevating virus()
has PubMed Central identifier	PMC7119811
has PubMed identifier	3998124
schema:publication	J Neuroimmunol
resource representing a document's body	covid:313d267468273358ccb89b3df7091e2b788b27cf#body_text
is schema:about of	named entity 'central nervous system' named entity 'infection' named entity 'lesions' named entity 'ENHANCEMENT' named entity '5728' named entity 'MICE' named entity 'PHONE' named entity 'INTENSE' named entity 'INFECTION' named entity 'ADJUVANT' named entity 'U.S.A.' named entity 'LESIONS' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'SCIENCE' named entity 'LACTATE DEHYDROGENASE-ELEVATING VIRUS' named entity 'INFECTED' named entity 'SPINAL CORD TISSUE' named entity 'LAKE CITY' named entity '2403' named entity 'MYCOBACTERIAL' named entity 'COMPONENT' named entity 'EXT' named entity 'DIVISION' named entity 'ENHANCING' named entity 'ELEMENT' named entity '1565' named entity 'CRITICAL' named entity '1985' named entity 'lesions' named entity '801' named entity 'U.S.A.' named entity 'Infected' named entity 'adjuvant' named entity 'mycobacterial' named entity 'CNS' named entity 'histologic' named entity 'virus' named entity 'white matter' named entity 'inflammatory disease' named entity 'histologic' named entity 'mode of action' named entity 'EAE' named entity 'RNA virus' named entity 'virus' named entity 'antigenic' named entity 'Double stranded' named entity 'CNS' named entity 'myelitis' named entity 'inflammation' named entity 'neurologic signs' named entity 'CNS' named entity 'effector cells' named entity 'spinal cord' named entity 'mice' named entity 'mice' named entity 'M. tuberculosis' named entity 'parenchyma' named entity 'leptomeninges' named entity 'paralytic poliomyelitis' named entity 'EAE' named entity 'mice' named entity 'white matter' named entity 'mice' named entity 'lactate dehydrogenase-elevating virus' named entity 'Chi-square analysis' named entity 'spinal cord' named entity 'EAE' named entity 'inoculation' named entity 'emulsified' named entity 'virus infection' named entity 'inflammation' named entity 'perfusion' named entity 'polyribonucleotide' named entity 'aging process' named entity 'histocompatibility' named entity 'inoculation' named entity 'CNS' named entity 'clinical signs' named entity 'lesion' named entity 'mice'

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