About: Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury
Creator	Bhattacharya, Sabyasachi Zhao, Bin Zheng, Hui Brice, Angela Girondo, Melanie Reichert, Maximilian Rui, Hallgeir Srinivasan, Satish Takano, Shigetsugu Yu, Qiujing Avadhani, Narayan Carbone, Christopher Fuchs, Serge Katlinskaya, Yuliya Katlinski, Kanstantsin Leu, Adrian May, Michael Mccorkell, Kelly Rustgi, Anil
Source	PMC
abstract	Type 1 interferons (IFN) protect the host against viruses by engaging a cognate receptor (consisting of IFNAR1/IFNAR2 chains) and inducing downstream signaling and gene expression. However, inflammatory stimuli can trigger IFNAR1 ubiquitination and downregulation thereby attenuating IFN effects in vitro. The significance of this paradoxical regulation is unknown. Presented here results demonstrate that inability to stimulate IFNAR1 ubiquitination in the Ifnar1(SA) knock-in mice renders them highly susceptible to numerous inflammatory syndromes including acute and chronic pancreatitis, and autoimmune and toxic hepatitis. Ifnar1(SA) mice (or their bone marrow-receiving wild type animals) display persistent immune infiltration of inflamed tissues, extensive damage and gravely inadequate tissue regeneration. Pharmacologic stimulation of IFNAR1 ubiquitination is protective against from toxic hepatitis and fulminant generalized inflammation in wild type but not Ifnar1(SA) mice. These results suggest that endogenous mechanisms that trigger IFNAR1 ubiquitination for limiting the inflammation-induced tissue damage can be purposely mimicked for therapeutic benefits. Subject Categories Immunology; Digestive System
has issue date	2014-01-31(xsd:dateTime)
bibo:doi	10.1002/emmm.201303236
bibo:pmid	24480543
has license	cc-by
sha1sum (hex)	3159f6ba739648bbaa0b8b7eb498924a8d21cf8e
schema:url	https://doi.org/10.1002/emmm.201303236
resource representing a document's title	Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury
has PubMed Central identifier	PMC3958312
has PubMed identifier	24480543
schema:publication	EMBO Mol Med
resource representing a document's body	covid:3159f6ba739648bbaa0b8b7eb498924a8d21cf8e#body_text
is schema:about of	named entity 'stimulation' named entity 'numerous' named entity 'engaging' named entity 'inflammatory' covid:arg/3159f6ba739648bbaa0b8b7eb498924a8d21cf8e named entity 'tissue' named entity 'tissues' named entity 'receptor' named entity 'mimicked' named entity 'persistent' named entity 'However' named entity 'ubiquitination' named entity 'stimulate' named entity 'host' named entity 'animals' named entity 'ubiquitination' named entity 'mice' named entity 'knock-in' named entity 'wild type' named entity 'IFN' named entity 'IFNAR1' named entity 'Ifnar1' named entity 'tissue damage' named entity 'Pharmacologic' named entity 'IFNAR1' named entity 'chronic pancreatitis' named entity 'hepatitis' named entity 'wild type' named entity 'IFNAR1' named entity 'trypsin' named entity 'receptor' named entity 'Acetaminophen' named entity 'staining' named entity 'septic shock' named entity 'cytokine' named entity 'inflammatory cytokines' named entity 'Irf7' named entity 'downregulation' named entity 'protein' named entity 'Ifnar1' named entity 'IFNAR1' named entity 'ubiquitination' named entity 'pancreatitis' named entity 'type 1 interferons' named entity 'viruses' named entity 'caerulein' named entity 'mRNA' named entity 'ubiquitination' named entity 'IFN' named entity 'inflammation' named entity 'serum' named entity 'p38' named entity 'IL10' named entity 'Moraga' named entity 'IFNAR1' named entity 'TNFa' named entity 'kinase' named entity 'endogenous' named entity 'mice' named entity 'inflammation' named entity 'extracellular domain' named entity 'hypertrophy' named entity 'pancreas'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software