About: Design, construction and validation of a nose‐only inhalation exposure system to measure infectivity of filtered bioaerosols in mice

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About: Design, construction and validation of a nose‐only inhalation exposure system to measure infectivity of filtered bioaerosols in mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Design, construction and validation of a nose‐only inhalation exposure system to measure infectivity of filtered bioaerosols in mice
Creator	Wu, C.-Y Heimbuch, B Wander, J Correspondence, Joseph Stone, B Wander,
topic	covid:31b864682a988b903df49da5b227ca60dae77508#this
Source	Medline; PMC
abstract	AIMS: The aim of this project was to validate a method to deliver a reproducible, selected dose of infective bioaerosol through a respiratory protective technology to an animal that exhibits a proportional clinical response. METHODS AND RESULTS: The Controlled Aerosol Test System (CATS) was designed to generate and condition a viable infective aerosol, pass it through a treatment technology and thence to the breathing zone of a mouse constrained in a Nose‐Only Inhalation Exposure System (NOIES). A scanning mobility particle sizer and impingers at sampling ports were used to show that viability is preserved and particle size distribution (PSD) is acceptably uniform throughout the open CATS, including the 12 ports of the NOIES, and that a particle filter used caused the expected attenuation of particle counts. CONCLUSIONS: Controlled Aerosol Test System delivers uniformly to mice constrained in the NOIES a selectable dose of viral bioaerosol whose PSD and viable counts remain consistent for an hour. SIGNIFICANCE AND IMPACT OF THE STUDY: This study's characterization of CATS provides a new test system in which a susceptible small‐animal model can be used as the detector in a quantitative method to evaluate the ability of respiratory protective technologies to attenuate the infectivity of an inspired pathogenic aerosol. This provides a major improvement over the use of viable bioaerosol collectors (e.g. impactors and impingers), which provide data that are difficult to relate to the attenuation of pathogenicity.
has issue date	2012-08-21(xsd:dateTime)
bibo:doi	10.1111/j.1365-2672.2012.05403.x
bibo:pmid	22817383
has license	no-cc
sha1sum (hex)	31b864682a988b903df49da5b227ca60dae77508
schema:url	https://doi.org/10.1111/j.1365-2672.2012.05403.x
resource representing a document's title	Design, construction and validation of a nose‐only inhalation exposure system to measure infectivity of filtered bioaerosols in mice
has PubMed Central identifier	PMC7166589
has PubMed identifier	22817383
schema:publication	J Appl Microbiol
resource representing a document's body	covid:31b864682a988b903df49da5b227ca60dae77508#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/31b864682a988b903df49da5b227ca60dae77508
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