About: SARS-CoV-2 infection, disease and transmission in domestic cats

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About: SARS-CoV-2 infection, disease and transmission in domestic cats Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	SARS-CoV-2 infection, disease and transmission in domestic cats
Creator	García-Sastre, Adolfo Carossino, Mariano Henningson, Jamie Kwon, Taeyong Balasuriya, Udeni Richt, Juergen Indran, Sabarish Balaraman, Velmurugan Bold, Dashzeveg Gaudreault, Natasha Madden, Daniel Meekins, David Trujillo, Jessie Wilson, William Cool, Konner Libanori Artiaga, Bianca Morozov,
source	BioRxiv
abstract	Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the cause of Coronavirus Disease 2019 (COVID-19) and responsible for the current pandemic. Recent SARS-CoV-2 susceptibility and transmission studies in cats show that the virus can replicate in these companion animals and transmit to other cats. Here, we present an in-depth study of SARS-CoV-2 infection, associated disease and transmission dynamics in domestic cats. Six 4- to 5-month-old cats were challenged with SARS-CoV-2 via intranasal and oral routes simultaneously. One day post challenge (DPC), two sentinel contact cats were co-mingled with the principal infected animals. Animals were monitored for clinical signs, clinicopathological abnormalities and viral shedding throughout the 21 DPC observation period. Postmortem examinations were performed at 4, 7 and 21 DPC to investigate disease progression. Viral RNA was not detected in blood but transiently in nasal, oropharyngeal and rectal swabs and bronchoalveolar lavage fluid as well as various tissues. Tracheobronchoadenitis of submucosal glands with the presence of viral RNA and antigen was observed in airways of the infected cats on 4 and 7 DPC. Serology showed that both, principal and sentinel cats, developed SARS-CoV-2-specific and neutralizing antibodies to SARS-CoV-2 detectable at 7 DPC or 10 DPC, respectively. All animals were clinically asymptomatic during the course of the study and capable of transmitting SARS-CoV-2 to sentinels within 2 days of comingling. The results of this study are critical for our understanding of the clinical course of SARS-CoV-2 in a naturally susceptible host species, and for risk assessment of the maintenance of SARS-CoV-2 in felines and transmission to other animals and humans.
has issue date	2020-08-04(xsd:dateTime)
bibo:doi	10.1101/2020.08.04.235002
has license	biorxiv
sha1sum (hex)	31bc6f84dfe9ec947d06932ad85e039d7153cfdc
schema:url	https://doi.org/10.1101/2020.08.04.235002
resource representing a document's title	SARS-CoV-2 infection, disease and transmission in domestic cats
schema:publication	bioRxiv
resource representing a document's body	covid:31bc6f84dfe9ec947d06932ad85e039d7153cfdc#body_text
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