About: Opportunistic intruders: how viruses orchestrate ER functions to infect cells

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Opportunistic intruders: how viruses orchestrate ER functions to infect cells
Creator	Bagchi, Parikshit Tsai, Corey, Nathaniel Cunningham, Billy Sudhan, Madhu
Source	Medline; PMC
abstract	Viruses subvert the functions of their host cells to replicate and form new viral progeny. The endoplasmic reticulum (ER) has been identified as a central organelle that governs the intracellular interplay between viruses and hosts. In this Review, we analyse how viruses from vastly different families converge on this unique intracellular organelle during infection, co-opting some of the endogenous functions of the ER to promote distinct steps of the viral life cycle from entry and replication to assembly and egress. The ER can act as the common denominator during infection for diverse virus families, thereby providing a shared principle that underlies the apparent complexity of relationships between viruses and host cells. As a plethora of information illuminating the molecular and cellular basis of virus–ER interactions has become available, these insights may lead to the development of crucial therapeutic agents.
has issue date	2016-06-06(xsd:dateTime)
bibo:doi	10.1038/nrmicro.2016.60
bibo:pmid	27265768
has license	green-oa
sha1sum (hex)	31c0580bd7d3104576c4a4f6ab6b6e66f0f4b3d7
schema:url	https://doi.org/10.1038/nrmicro.2016.60
resource representing a document's title	Opportunistic intruders: how viruses orchestrate ER functions to infect cells
has PubMed Central identifier	PMC5272919
has PubMed identifier	27265768
schema:publication	Nature Reviews Microbiology
resource representing a document's body	covid:31c0580bd7d3104576c4a4f6ab6b6e66f0f4b3d7#body_text
is schema:about of	named entity 'TO INFECT' named entity 'interactions' named entity 'functions' named entity 'Viruses' named entity 'intracellular' named entity 'IDENTIFIED' named entity 'DEVELOPMENT' named entity 'MOLECULAR' named entity 'HOST CELLS' named entity 'VIRUSES' named entity 'APPARENT' named entity 'COMPLEXITY' named entity 'PROMOTE' named entity 'INTRACELLULAR' named entity 'CELLULAR' named entity 'REPLICATION' named entity 'FUNCTIONS' named entity 'CELLS' named entity 'VIRUSES' named entity 'HOW' named entity 'ASSEMBLY' named entity 'ORGANELLE' named entity 'INFECTION' named entity 'FUNCTIONS' named entity 'VIRAL' named entity 'VIRAL LIFE CYCLE' named entity 'DISTINCT' named entity 'HOW' named entity 'PRINCIPLE' named entity 'INFORMATION' named entity 'ENDOPLASMIC RETICULUM' named entity 'FAMILIES' named entity 'INTRACELLULAR ORGANELLE' named entity 'AVAILABLE' named entity 'VIRUS' named entity 'INSIGHTS' named entity 'PROVIDING' named entity 'DENOMINATOR' named entity 'THESE' named entity 'DIFFERENT' named entity 'CENTRAL' named entity 'THEIR' named entity 'ENTRY' named entity 'UNIQUE' named entity 'DIVERSE' named entity 'COMMON' named entity 'FORM' named entity 'NEW' named entity 'PROGENY' named entity 'STEPS' named entity 'ACT' named entity 'ENDOGENOUS' named entity 'REPLICATE' named entity 'BASIS' named entity 'PLETHORA' named entity 'SHARED' named entity 'INTERACTIONS' named entity 'HOSTS' named entity 'RELATIONSHIPS' named entity 'THERAPEUTIC AGENTS' named entity 'CONVERGE' named entity 'LEAD' named entity 'REVIEW' named entity 'interplay' named entity 'insights' named entity 'replication' named entity 'co-opting' named entity 'endoplasmic reticulum' named entity 'lead' named entity 'endogenous' named entity 'cellular' named entity 'virus' named entity 'intracellular' named entity 'viruses' named entity 'host cells' named entity 'governs' named entity 'organelle'

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