About: The use of thromboelastography to assess post-operative changes in coagulation and predict graft function in renal transplantation()

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About: The use of thromboelastography to assess post-operative changes in coagulation and predict graft function in renal transplantation() Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The use of thromboelastography to assess post-operative changes in coagulation and predict graft function in renal transplantation()
Creator	Choudhury, Rashikh Moore, Hunter Nydam, Trevor Adams, Megan Bak, Thomas Chapman, Michael Conzen, Kendra Kennealey, Peter Pomfret, Elizabeth Pomposelli, James Pshak, Thomas Schulick, Alexander Wachs, Michael Walker, Carson Yaffe, Hillary
Source	Elsevier; PMC
abstract	BACKGROUND: End stage renal disease (ESRD) is associated with elevated fibrinogen levels and fibrinolysis inhibition. However, there is a paucity of data on how renal transplantation impacts coagulation. we hypothesize that renal transplantation recipients with good functioning grafts will have improved fibrinolytic activity following surgery. METHODS: Kidney recipients were analyzed pre-operatively and on post-operative day 1(POD1) using three different TEG assays with and without two concentration of tissue-plasminogen activator (t-PA). TEG indices and percent reduction in creatinine from pre-op to POD1 were measured, with >50% defining “good” graft function. Follow up was done at 6, 12, and 24 months. RESULTS: Percent lysis(LY30) on POD1 the t-PA TEG was significantly correlated to change creatinine from pre-op to POD-1(p = 0.006). A LY30 ≥ 23% was associated with good early graft function, and lower creatinine at 24-months(p = 0.028) compared to recipients with low POD1 LY30. CONCLUSIONS: Post-operative tPA-TEG LY30 is associated with favorable early and late outcomes in kidney transplant.
has issue date	2020-08-27(xsd:dateTime)
bibo:doi	10.1016/j.amjsurg.2020.08.019
has license	no-cc
sha1sum (hex)	31c8672d41aec898a15fa7ed92dbf917c14fb39e
schema:url	https://doi.org/10.1016/j.amjsurg.2020.08.019
resource representing a document's title	The use of thromboelastography to assess post-operative changes in coagulation and predict graft function in renal transplantation()
has PubMed Central identifier	PMC7450953
schema:publication	Am J Surg
resource representing a document's body	covid:31c8672d41aec898a15fa7ed92dbf917c14fb39e#body_text
is schema:about of	named entity 'Transplantation' named entity 'Journal' named entity 'ESRD' named entity 'elevated' named entity 'coagulation' named entity 'Thromboelastography' named entity 'Renal Transplantation' named entity 'fibrinolysis' named entity 'creatinine' named entity 't-PA' named entity 'organ' named entity 'blood samples' named entity 'systemic inflammation' named entity 'ischemic' named entity 'coagulation factors' named entity 'Animal work' named entity 'cost-effective' named entity 'Armonk' named entity 'thrombin' named entity 'liver transplantation' named entity 'fibrinogen' named entity 'coagulation' named entity 'Renal failure' named entity 'post-operative' named entity 'fibrinolytic' named entity 'ESRD' named entity '3.5' named entity 'POD1' named entity 'autoimmune disease' named entity 'hemodialysis access' named entity 'coagulation' named entity 'creatinine' named entity 'lysis' named entity 'blood samples' named entity 'coagulation' named entity 't-PA' named entity 'fibrin' named entity 'kidneys' named entity 'fibrinolysis' named entity 'polycystic kidney disease' named entity 'animal models' named entity 't-PA' named entity 'dialysis' named entity 'intravascular' named entity 'deep vein thrombosis' named entity 'Haemonetics' named entity 'ESRD' named entity 't-PA' named entity 'long-term' named entity 'uPA' named entity 'hypertension' named entity 'dialysis' named entity 'coagulation' named entity 'Thymoglobulin' named entity 'COVID-19 pandemic' named entity 'perfusion' named entity 't-PA' named entity 'creatinine' named entity 'lysis' named entity 'POD1' named entity 'perioperative' named entity 'kidney transplantation' named entity 'fibrinolysis' named entity 'kidneys' named entity 'renal transplantation' named entity 'tPA' named entity 'living donor' named entity 'hypertension' named entity 't-PA'

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