About: Squalene-based multidrug nanoparticles for improved mitigation of uncontrolled inflammation in rodents

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Squalene-based multidrug nanoparticles for improved mitigation of uncontrolled inflammation in rodents
Creator	Brusini, Romain Couvreur, Patrick Varna, Mariana Cailleau, Catherine Dormont, Flavio Gaudin, Françoise Gendron, Amandine Mougin, Julie Peramo, Arnaud Reynaud, Franceline
Source	Medline; PMC
abstract	Uncontrolled inflammatory processes are at the root of numerous pathologies. Most recently, studies on confirmed COVID-19 cases have suggested that mortality might be due to virally induced hyperinflammation. Uncontrolled pro-inflammatory states are often driven by continuous positive feedback loops between pro-inflammatory signaling and oxidative stress, which cannot be resolved in a targeted manner. Here, we report on the development of multidrug nanoparticles for the mitigation of uncontrolled inflammation. The nanoparticles are made by conjugating squalene, a natural lipid, to adenosine, an endogenous immunomodulator, and then encapsulating α-tocopherol, as antioxidant. This resulted in high drug loading, biocompatible, multidrug nanoparticles. By exploiting the endothelial dysfunction at sites of acute inflammation, these multidrug nanoparticles delivered the therapeutic agents in a targeted manner, conferring survival advantage to treated animals in models of endotoxemia. Selectively delivering adenosine and antioxidants together could serve as a novel therapeutic approach for safe treatment of acute paradoxal inflammation.
has issue date	2020-06-05(xsd:dateTime)
bibo:doi	10.1126/sciadv.aaz5466
bibo:pmid	32548259
has license	cc-by-nc
sha1sum (hex)	31cb5f2e9b24ce89af521661797995ecbbbc74f2
schema:url	https://doi.org/10.1126/sciadv.aaz5466
resource representing a document's title	Squalene-based multidrug nanoparticles for improved mitigation of uncontrolled inflammation in rodents
has PubMed Central identifier	PMC7274527
has PubMed identifier	32548259
schema:publication	Sci Adv
resource representing a document's body	covid:31cb5f2e9b24ce89af521661797995ecbbbc74f2#body_text
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