About: Randomized Controlled Study Evaluating Efficiency of Low Intensity Transcranial Direct Current Stimulation (tDCS) for Dyspnea Relief in Mechanically Ventilated COVID-19 Patients in ICU: The tDCS-DYSP-COVID Protocol

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About: Randomized Controlled Study Evaluating Efficiency of Low Intensity Transcranial Direct Current Stimulation (tDCS) for Dyspnea Relief in Mechanically Ventilated COVID-19 Patients in ICU: The tDCS-DYSP-COVID Protocol Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Randomized Controlled Study Evaluating Efficiency of Low Intensity Transcranial Direct Current Stimulation (tDCS) for Dyspnea Relief in Mechanically Ventilated COVID-19 Patients in ICU: The tDCS-DYSP-COVID Protocol
Creator	Annane, Djillali Resche-Rigon, Matthieu Spain, Azabou, Eric Moine, Pierre Sharshar, Tarek Bao, Guillaume Bounab, Rania Chevallier, Sylvain Chevret, Sylvie Heming, Nicholas Lofaso, Frederic Siami, Shidaps Dileone, Michele Jamil, Asif Puerto, Del
Source	Medline; PMC
abstract	The severe respiratory distress syndrome linked to the new coronavirus disease (COVID-19) includes unbearable dyspneic suffering which contributes to the deterioration of the prognosis of patients in intensive care unit (ICU). Patients are put on mechanical ventilation to reduce respiratory suffering and preserve life. Despite this mechanical ventilation, most patients continue to suffer from dyspnea. Dyspnea is a major source of suffering in intensive care and one of the main factors that affect the prognosis of patients. The development of innovative methods for its management, especially non-drug management is more than necessary. In recent years, numerous studies have shown that transcranial direct current stimulation (tDCS) could modulate the perception of acute or chronic pain. In the other hand, it has been shown that the brain zones activated during pain and dyspnea are close and/or superimposed, suggesting that brain structures involved in the integration of aversive emotional component are shared by these two complex sensory experiences. Therefore, it can be hypothesized that stimulation by tDCS with regard to the areas which, in the case of pain have activated one or more of these brain structures, may also have an effect on dyspnea. In addition, our team recently demonstrated that the application of tDCS on the primary cortical motor area can modulate the excitability of the respiratory neurological pathways. Indeed, tDCS in anodal or cathodal modality reduced the excitability of the diaphragmatic cortico-spinal pathways in healthy subjects. We therefore hypothesized that tDCS could relieve dyspnea in COVID-19 patients under mechanical ventilation in ICU. This study was designed to evaluate effects of two modalities of tDCS (anodal and cathodal) vs. placebo, on the relief of dyspnea in COVID-19 patients requiring mechanical ventilation in ICU. Trial Registration: This protocol is derived from the tDCS-DYSP-REA project registered on ClinicalTrials.gov NCT03640455. It will however be registered under its own NCT number.
has issue date	2020-06-26(xsd:dateTime)
bibo:doi	10.3389/fmed.2020.00372
bibo:pmid	32671084
has license	cc-by
sha1sum (hex)	31da1b7d569d81bbcd9c2aa2181ae6bb89477473
schema:url	https://doi.org/10.3389/fmed.2020.00372
resource representing a document's title	Randomized Controlled Study Evaluating Efficiency of Low Intensity Transcranial Direct Current Stimulation (tDCS) for Dyspnea Relief in Mechanically Ventilated COVID-19 Patients in ICU: The tDCS-DYSP-COVID Protocol
has PubMed Central identifier	PMC7332773
has PubMed identifier	32671084
schema:publication	Front Med (Lausanne)
resource representing a document's body	covid:31da1b7d569d81bbcd9c2aa2181ae6bb89477473#body_text
is schema:about of	named entity 'REA' named entity 'TRIAL' named entity 'PROTOCOL' named entity 'tDCS' named entity 'NCT' named entity 'Randomized Controlled Study' named entity 'tDCS' named entity 'STUDY PROTOCOL' named entity 'Mechanically Ventilated' named entity 'ICU' named entity 'informed consent' named entity 'tDCS' named entity 'CO2 sensor' named entity 'cathodal' named entity 'EEG' named entity 'Pierre Marie' named entity 'brain structures' named entity 'dyspnea' named entity 'tDCS' named entity 'neurological examination' named entity 'tDCS' named entity 'placebo-controlled' named entity 'placebo' named entity 'amplitude' named entity 'glycemia' named entity 'Fisher test' named entity 'dyspnea' named entity 'cathodal' named entity 'transcranial direct current stimulation' named entity 'COVID-19' named entity 'experimental group' named entity 'ICU' named entity 'tDCS' named entity 'Coronavirus disease' named entity 'dyspnea' named entity 'cumulative incidence' named entity '28 days' named entity 'functional imaging' named entity 'neurological' named entity 'medical device' named entity 'resuscitation' named entity 'dyspnea' named entity 'pre-motor cortex' named entity 'tDCS' named entity 'dyspnea' named entity 'dyspnea' named entity 'mechanical ventilation' named entity 'tDCS' named entity 'pathology' named entity 'mechanical ventilation' named entity 'intensive care' named entity 'tDCS' named entity 'COVID-19' named entity 'dyspnea' named entity 'tDCS' named entity 'chronic pain' named entity 'current density' named entity 'respiration' named entity 'breathing difficulty' named entity 'PPIs' named entity 'amplitude' named entity 'placebo' named entity 'placebo group' named entity 'dyspnea' named entity 'visual analog scale' named entity 'facial expression'

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