About: Acute Flaccid Myelitis in Children in Zhejiang Province, China

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Acute Flaccid Myelitis in Children in Zhejiang Province, China
Creator	Chen, Chen Gao, Feng Zhang, Yanjun Chen, Yin Sun, Yi Wang, Y Xu, Lu Zhang, Zhao Kesson, Alison Yan, Juying Wang, Yilong Zhao, Zhengyan Gong, L Ge, Qiong Gong, Liming Jiang, Lihua Jiang, Peifang Jiang, Xia Melaiki, Brahim Xia, Zhezhi Yang, Xinghui Yuan, Zhefeng Zhang, Weiqing Zhao, Congying
Source	Medline; PMC
abstract	In July–December 2018, an outbreak of polio-like acute flaccid myelitis (AFM) occurred in Zhejiang province, China. Enterovirus (EV)-D68 infection has been reported to be associated with AFM. This study aimed to investigate the clinical presentation, laboratory findings, and outcomes of AFM patients. We investigated the clinical and virologic information regarding the AFM patients, and real-time PCR, sequencing, and phylogenetic analysis were used to investigate the cause of AFM. Eighteen cases met the definition of AFM, with a median age of 4.05 years (range, 0.9–9 years), and nine (50%) were EV-D68 positive. Symptoms included acute flaccid limb weakness and cranial nerve dysfunction. On magnetic resonance imaging, 11 (61.1%) patients had spinal gray matter abnormalities. Electromyography results of 16 out of 17 patients (94.1%) were abnormal. Cerebrospinal fluid (CSF) pleocytosis was common (94.4%), while CSF protein concentration was normal in all patients. There was little improvement after early aggressive therapy. Phylogenetic analysis revealed that EV-D68 subclade B3 was the predominant lineage circulating in Zhejiang province in 2018.
has issue date	2020-05-22(xsd:dateTime)
bibo:doi	10.3389/fneur.2020.00360
bibo:pmid	32528396
has license	cc-by
sha1sum (hex)	32149dd10a887c3adb50d3b04f1cf07421057167
schema:url	https://doi.org/10.3389/fneur.2020.00360
resource representing a document's title	Acute Flaccid Myelitis in Children in Zhejiang Province, China
has PubMed Central identifier	PMC7256184
has PubMed identifier	32528396
schema:publication	Front Neurol
resource representing a document's body	covid:32149dd10a887c3adb50d3b04f1cf07421057167#body_text
is schema:about of	covid:arg/32149dd10a887c3adb50d3b04f1cf07421057167 named entity 'pleocytosis' named entity 'AFM' named entity 'Phylogenetic analysis' named entity 'AFM' named entity 'AFM' named entity 'virologic' named entity 'protein' named entity 'phylogenetic analysis' named entity 'Electromyography' named entity 'clinical presentation' named entity 'Zhejiang Province' named entity 'AFM' named entity 'Qiagen' named entity 'MRI' named entity 'human rhinovirus' named entity 'genomic analysis' named entity 'corticosteroids' named entity 'AFM' named entity 'EV-D68' named entity 'AFM' named entity 'EMG' named entity 'EMG' named entity 'CSF pleocytosis' named entity 'EMG' named entity 'epidemiological' named entity 'AFM' named entity 'muscle strength' named entity 'EV-D68' named entity 'neurological symptoms' named entity 'human coronavirus' named entity 'human parainfluenza virus' named entity 'neonatal' named entity 'AFM' named entity 'Fisher's Exact Test' named entity 'EV-D68' named entity 'EV-D68' named entity 'Guillain-Barré syndrome' named entity 'brain MRI' named entity 'AFM' named entity 'anterior horn cell' named entity 'Zhejiang University School of Medicine' named entity 'EV-D68' named entity 'respiratory symptoms' named entity 'Italy' named entity 'Vietnam' named entity 'AFM' named entity 'EV-D68' named entity 'lumbar' named entity 'Guillain-Barré syndrome' named entity 'China' named entity 'CSF glucose' named entity 'muscle' named entity 'enterovirus' named entity 'RNA' named entity 'EV-D68' named entity 'glucose' named entity 'white blood cell count'

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