About: Detection of Acute HIV-1 Infection by RT-LAMP

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Detection of Acute HIV-1 Infection by RT-LAMP
Creator	Sullivan, Vickie Curtis, Kelly Owen, S Rudolph, Donna
Source	PMC
abstract	A rapid, cost-effective diagnostic test for the detection of acute HIV-1 infection is highly desired. Isothermal amplification techniques, such as reverse-transcription loop-mediated isothermal amplification (RT-LAMP), exhibit characteristics that are ideal for the development of a rapid nucleic acid amplification test (NAAT) because they are quick, easy to perform and do not require complex, dedicated equipment and laboratory space. In this study, we assessed the ability of the HIV-1 RT-LAMP assay to detect acute HIV infection as compared to a representative rapid antibody test and several FDA-approved laboratory-based assays. The HIV-1 RT-LAMP assay detected seroconverting individuals one to three weeks earlier than a rapid HIV antibody test and up to two weeks earlier than a lab-based antigen/antibody (Ag/Ab) combo enzyme immunoassay (EIA). RT-LAMP was not as sensitive as a lab-based qualitative RNA assay, which could be attributed to the significantly smaller nucleic acid input volume. To our knowledge, this is the first demonstration of detecting acute HIV infection using the RT-LAMP assay. The availability of a rapid NAAT, such as the HIV-1 RT-LAMP assay, at the point of care (POC) or in laboratories that do not have access to large platform NAAT could increase the percentage of individuals who receive an acute HIV infection status or confirmation of their HIV status, while immediately linking them to counseling and medical care. In addition, early knowledge of HIV status could lead to reduced high-risk behavior at a time when individuals are at a higher risk for transmitting the virus.
has issue date	2015-05-20(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0126609
bibo:pmid	25993381
has license	cc0
sha1sum (hex)	3236c24e4656add3fbf17ed686d2b7c73bb52de9
schema:url	https://doi.org/10.1371/journal.pone.0126609
resource representing a document's title	Detection of Acute HIV-1 Infection by RT-LAMP
has PubMed Central identifier	PMC4439053
has PubMed identifier	25993381
schema:publication	PLoS One
resource representing a document's body	covid:3236c24e4656add3fbf17ed686d2b7c73bb52de9#body_text
is schema:about of	named entity 'rapid' named entity 'HIV' named entity 'sensitive' named entity 'RNA' named entity 'rapid' named entity 'assay' named entity 'LAMP' named entity 'HIV STATUS' named entity 'DEVELOPMENT' named entity 'APPROVED' named entity 'ANTIBODY TEST' covid:arg/3236c24e4656add3fbf17ed686d2b7c73bb52de9 named entity 'RISK' named entity 'TIME' named entity 'RNA ASSAY' named entity 'HIV-1 INFECTION' named entity 'DEMONSTRATION' named entity 'TO DETECT' named entity 'AMPLIFICATION' named entity 'INFECTION STATUS' named entity 'IDEAL' named entity 'COST' named entity 'ENZYME IMMUNOASSAY' named entity 'USING' named entity 'COMPARED' named entity 'OUR' named entity 'COULD BE' named entity 'SMALLER' named entity 'LABORATORY' named entity 'REDUCED' named entity 'DETECTION' named entity 'HIV ANTIBODY TEST' named entity 'EARLIER' named entity 'KNOWLEDGE' named entity 'ACCESS' named entity 'HAVE' named entity 'VIRUS' named entity 'QUICK' named entity 'NUCLEIC ACID AMPLIFICATION TEST' named entity 'ACUTE' named entity 'MEDICAL CARE' named entity 'REPRESENTATIVE' named entity 'QUALITATIVE' named entity 'CONFIRMATION OF' named entity 'DETECTION' named entity 'ACUTE' named entity 'RT-LAMP ASSAY' named entity 'DETECTING' named entity 'RAPID' named entity 'INDIVIDUALS' named entity 'INCREASE' named entity 'DIAGNOSTIC TEST' named entity 'PERFORM' named entity 'HIV-1' named entity 'PLATFORM' named entity 'DEDICATED' named entity 'COUNSELING' named entity 'ANTIGEN' named entity 'REVERSE-TRANSCRIPTION' named entity 'EXHIBIT' named entity 'BASED' named entity 'TRANSMITTING' named entity 'HIGHLY' named entity 'UP TO' named entity 'ADDITION' named entity 'LEAD' named entity 'TWO WEEKS' named entity 'RECEIVE' named entity 'FDA' named entity 'ACUTE HIV INFECTION' named entity 'EARLY' named entity 'VOLUME' named entity 'DO NOT' named entity 'POINT OF CARE' named entity 'NAAT' named entity 'LARGE' named entity 'DETECTED' named entity 'LINKING'

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