About: Kinetic Modelling of Infection Tracers [(18)F]FDG, [(68)Ga]Ga-Citrate, [(11)C]Methionine, and [(11)C]Donepezil in a Porcine Osteomyelitis Model

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About: Kinetic Modelling of Infection Tracers [(18)F]FDG, [(68)Ga]Ga-Citrate, [(11)C]Methionine, and [(11)C]Donepezil in a Porcine Osteomyelitis Model Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Kinetic Modelling of Infection Tracers [(18)F]FDG, [(68)Ga]Ga-Citrate, [(11)C]Methionine, and [(11)C]Donepezil in a Porcine Osteomyelitis Model
Creator	Nielsen, Ole Afzelius, Pia Borghammer, Per Jødal, Lars Alstrup, Aage Hansen, Søren Jensen, Svend
Source	PMC
abstract	INTRODUCTION: Positron emission tomography (PET) is increasingly applied for infection imaging using [(18)F]FDG as tracer, but uptake is unspecific. The present study compares the kinetics of [(18)F]FDG and three other PET tracers with relevance for infection imaging. METHODS: A juvenile porcine osteomyelitis model was used. Eleven pigs underwent PET/CT with 60-minute dynamic PET imaging of [(18)F]FDG, [(68)Ga]Ga-citrate, [(11)C]methionine, and/or [(11)C]donepezil, along with blood sampling. For infectious lesions, kinetic modelling with one- and two-tissue-compartment models was conducted for each tracer. RESULTS: Irreversible uptake was found for [(18)F]FDG and [(68)Ga]Ga-citrate; reversible uptake was found for [(11)C]methionine (two-tissue model) and [(11)C]donepezil (one-tissue model). The uptake rate for [(68)Ga]Ga-citrate was slow and diffusion-limited. For the other tracers, the uptake rate was primarily determined by perfusion (flow-limited uptake). Net uptake rate for [(18)F]FDG and distribution volume for [(11)C]methionine were significantly higher for infectious lesions than for correspondingly noninfected tissue. For [(11)C]donepezil in pigs, labelled metabolite products appeared to be important for the analysis. CONCLUSIONS: The kinetics of the four studied tracers in infection was characterized. For clinical applications, [(18)F]FDG remains the first-choice PET tracer. [(11)C]methionine may have a potential for detecting soft tissue infections. [(68)Ga]Ga-citrate and [(11)C]donepezil were not found useful for imaging of osteomyelitis.
has issue date	2017-10-09(xsd:dateTime)
bibo:doi	10.1155/2017/9256858
bibo:pmid	29114181
has license	cc-by
sha1sum (hex)	32501343a772539b8477e17940f7333e8678fe5f
schema:url	https://doi.org/10.1155/2017/9256858
resource representing a document's title	Kinetic Modelling of Infection Tracers [(18)F]FDG, [(68)Ga]Ga-Citrate, [(11)C]Methionine, and [(11)C]Donepezil in a Porcine Osteomyelitis Model
has PubMed Central identifier	PMC5654273
has PubMed identifier	29114181
schema:publication	Contrast Media Mol Imaging
resource representing a document's body	covid:32501343a772539b8477e17940f7333e8678fe5f#body_text
is schema:about of	named entity 'Methods' named entity 'slow' named entity 'dynamic' named entity 'lesions' named entity 'metabolite' named entity 'labelled' named entity 'detecting' named entity 'Modelling' named entity 'Porcine' named entity 'MODELLING' named entity 'HIGHER' named entity 'PERFUSION' named entity 'PRESENT' covid:arg/32501343a772539b8477e17940f7333e8678fe5f named entity 'RATE' named entity 'JUVENILE' named entity 'COMPARTMENT MODELS' named entity 'NET' named entity 'INFECTION' named entity 'NOT FOUND' named entity 'DETECTING' named entity 'CHOICE' named entity 'DIFFUSION' named entity 'MODEL' named entity 'STUDY' named entity 'CHARACTERIZED' named entity 'USEFUL' named entity 'DISTRIBUTION VOLUME' named entity 'CITRATE' named entity 'CONCLUSIONS' named entity 'SLOW' named entity 'TRACER' named entity 'INFECTION' named entity 'KINETIC' named entity 'CITRATE' named entity 'PRODUCTS' named entity 'KINETICS' named entity 'PIGS' named entity 'PORCINE' named entity 'BUT' named entity 'INFECTIOUS' named entity 'ANALYSIS' named entity 'METHODS' named entity 'MODELLING' named entity 'MINUTE' named entity 'RESULTS' named entity 'PET' named entity 'METABOLITE' named entity 'OSTEOMYELITIS' named entity 'KINETIC' named entity 'DETERMINED BY' named entity 'RELEVANCE' named entity 'APPLICATIONS' named entity 'TISSUE MODEL' named entity 'UPTAKE' named entity 'USED' named entity 'USING' named entity 'CLINICAL' named entity 'IRREVERSIBLE' named entity 'REVERSIBLE' named entity 'DYNAMIC' named entity 'MAY HAVE' named entity 'MODEL' named entity 'TISSUE' named entity 'IMAGING' named entity 'BLOOD SAMPLING' named entity 'INFECTION IMAGING' named entity 'LESIONS' named entity 'IMPORTANT' named entity 'TRACERS' named entity 'OSTEOMYELITIS' named entity 'SOFT TISSUE INFECTIONS' named entity 'PORCINE' named entity 'LIMITED' named entity 'POTENTIAL'

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