About: Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province

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About: Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province
Creator	Liu, Wei Liu, Kui Xiao, Wei Liu, Hui-Guo Deng, Yan Fang, Yuan-Yuan Li, Cheng-Hong Li, Guang-Cai Ma, Jing-Ping Wang, Mei-Fang Wang, Ying-Nan Zhong, Min-Hua Hao, Xiu-Yuan Liu, Wei, Pei-Fang Hui-Guo,
topic	covid:3258949ca406a5f503cee042ba1ee54663fb47f9#this
Source	Medline; PMC
abstract	BACKGROUND: A novel coronavirus (2019-nCoV) causing an outbreak of pneumonia in Wuhan, Hubei province of China was isolated in January 2020. This study aims to investigate its epidemiologic history, and analyze the clinical characteristics, treatment regimens, and prognosis of patients infected with 2019-nCoV during this outbreak. METHODS: Clinical data from 137 2019-nCoV-infected patients admitted to the respiratory departments of the respiratory departments of nine tertiary hospitals in Hubei province from December 30, 2019 to January 24, 2020 were retrospectively collected, including general status, clinical manifestations, laboratory test results, imaging characteristics, and treatment regimens. RESULTS: None of the 137 patients (61 males, 76 females, aged 20–83 years, median age 57 years) had a definite history of exposure to Huanan Seafood Wholesale Market. Major initial symptoms included fever (112/137, 81.8%), coughing (66/137, 48.2%), and muscle pain or fatigue (44/137, 32.1%), with other, less typical initial symptoms observed at low frequency, including heart palpitations, diarrhea, and headache. Nearly 80% of the patients had normal or decreased white blood cell counts, and 72.3% (99/137) had lymphocytopenia. Lung involvement was present in all cases, with most chest computed tomography scans showing lesions in multiple lung lobes, some of which were dense; ground-glass opacity co-existed with consolidation shadows or cord-like shadows. Given the lack of effective drugs, treatment focused on symptomatic and respiratory support. Immunoglobulin G was delivered to some critically ill patients according to their conditions. Systemic corticosteroid treatment did not show significant benefits. Notably, early respiratory support facilitated disease recovery and improved prognosis. The risk of death was primarily associated with age, underlying chronic diseases, and median interval from the appearance of initial symptoms to dyspnea. CONCLUSIONS: The majority of patients with 2019-nCoV pneumonia present with fever as the first symptom, and most of them still showed typical manifestations of viral pneumonia on chest imaging. Middle-aged and elderly patients with underlying comorbidities are susceptible to respiratory failure and may have a poorer prognosis.
has issue date	2020-02-07(xsd:dateTime)
bibo:doi	10.1097/cm9.0000000000000744
bibo:pmid	32044814
has license	no-cc
sha1sum (hex)	3258949ca406a5f503cee042ba1ee54663fb47f9
schema:url	https://doi.org/10.1097/cm9.0000000000000744
resource representing a document's title	Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province
has PubMed Central identifier	PMC7147277
has PubMed identifier	32044814
schema:publication	Chin Med J (Engl)
resource representing a document's body	covid:3258949ca406a5f503cee042ba1ee54663fb47f9#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/3258949ca406a5f503cee042ba1ee54663fb47f9
is schema:about of	named entity 'pneumonia' named entity 'Hubei' named entity 'causing' named entity 'females' named entity 'typical' named entity 'shadows' named entity 'fever' named entity 'early' named entity 'initial' named entity 'lung lobes' named entity 'manifestations' named entity 'symptom' named entity 'January 24' named entity 'SYMPTOMS' named entity 'CRITICALLY ILL' named entity 'LOBES' named entity 'NORMAL' named entity 'SUSCEPTIBLE' named entity 'MEDIAN' named entity 'RESPIRATORY' named entity 'TO INVESTIGATE' named entity 'counts' named entity 'coronavirus' named entity 'collected' named entity 'viral pneumonia' named entity 'interval' named entity 'respiratory' named entity 'Lung' named entity 'patients' named entity 'chest' named entity 'pneumonia' named entity 'symptoms' named entity '2019-nCoV' named entity 'Huanan Seafood Wholesale Market' named entity 'treatment regimens' named entity 'clinical characteristics' named entity 'headache' named entity '2019-nCoV' named entity 'coronavirus' named entity 'prognosis' named entity 'Clinical data' named entity 'respiratory support' named entity 'symptom' named entity 'pneumonia' named entity 'fever' named entity 'fatigue' named entity 'respiratory failure' named entity 'corticosteroid' named entity 'Clinical characteristics' named entity 'dyspnea' named entity 'fever' named entity 'Wuhan' named entity 'coughing' named entity 'critically ill patients' named entity '2019-nCoV' named entity 'chronic diseases' named entity 'lung lobes' named entity 'diarrhea' named entity 'coronavirus cases' named entity 'respiratory support' named entity 'Hubei province' named entity 'laboratory test' named entity 'comorbidities' named entity 'chest imaging'

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