About: Evaluation of multiple test methods for the detection of the novel 2009 influenza A (H1N1) during the New York City outbreak

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About: Evaluation of multiple test methods for the detection of the novel 2009 influenza A (H1N1) during the New York City outbreak Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evaluation of multiple test methods for the detection of the novel 2009 influenza A (H1N1) during the New York City outbreak
Creator	Ginocchio, Christine Lotlikar, Madhavi Manji, Ryhana Crawford, James Korologos, Diamanto Arora, Suman Becker, George Bornfreund, Mark Falk, Leon Kowerska, Margaret Zhang, Frank De Geronimo, Marcella
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: In response to the novel influenza A H1N1 outbreak in the NY City area, 6090 patient samples were submitted over a 5-week period for a total of 14,114 viral diagnostic tests, including rapid antigen, direct immunofluorescence (DFA), viral culture and PCR. Little was known about the performance of the assays for the detection of novel H1N1 in the background of seasonal H1N1, H3N2 and other circulating respiratory viruses. In addition, subtyping influenza A became critical for the identification of high risk and/or hospitalized patients with novel H1N1 infection and for monitoring the spread of the outbreak. STUDY DESIGN: This study analyzed the performances of the BinaxNOW Influenza A&B test (BinaxNOW), the 3M Rapid Detection Flu A + B test (3MA + B), direct immunofluorescence, R-Mix culture and the Luminex xTAG Respiratory Virus Panel (RVP) for the detection of seasonal influenza, novel H1N1 and other respiratory viruses. RVP was also evaluated for its ability to differentiate seasonal H1N1, H3N2 and novel H1N1. RESULTS: The sensitivities, specificities, PPVs and NPVs for the detection of novel H1N1, determined by comparing all four-test methods, were: rapid antigen: 17.8%, 93.6%, 77.4%, 47.9%; DFA: 46.7%, 94.5%, 91.3%, 58.9%; R-Mix culture: 88.9%, 100%, 100%, 87.9%; RVP: 97.8%, 100%, 100%, 97.3%. The individual sensitivities of BinaxNOW and 3MA + B as compared to R-Mix culture for the detection of novel H1N1 were 9.6% and 40%, respectively. All unsubtypeable influenza A specimens identified by RVP and tested with the CDC novel H1N1 specific RT-PCR assay were confirmed to be novel H1N1. CONCLUSIONS: Rapid antigen tests, DFA, R-Mix culture and the xTAG RVP test all detected the novel H1N1 strain, but with highly varied sensitivity. The RVP test provided the best diagnostic option as RVP demonstrated superior sensitivity for the detection of all influenza strains, including the novel H1N1, provided accurate influenza A subtyping and identified a significant number of additional respiratory pathogens.
has issue date	2009-06-16(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2009.06.005
bibo:pmid	19540158
has license	no-cc
sha1sum (hex)	327d892db0c7f31f556ba94bf7872d342f43738c
schema:url	https://doi.org/10.1016/j.jcv.2009.06.005
resource representing a document's title	Evaluation of multiple test methods for the detection of the novel 2009 influenza A (H1N1) during the New York City outbreak
has PubMed Central identifier	PMC7172175
has PubMed identifier	19540158
schema:publication	J Clin Virol
resource representing a document's body	covid:327d892db0c7f31f556ba94bf7872d342f43738c#body_text
is schema:about of	named entity 'Rapid' named entity 'outbreak' named entity 'identified' named entity 'culture' named entity 'period' named entity 'H1N1' named entity 'RVP' named entity 'test' named entity 'subtyping' named entity 'influenza A' named entity 'background' named entity 'detection' named entity 'H1N1' named entity 'H3N2' named entity 'area' named entity 'direct immunofluorescence' named entity 'culture' named entity 'outbreak' named entity 'response' named entity 'INCLUDING' named entity 'IDENTIFIED BY' named entity 'STUDY' named entity 'INDIVIDUAL' named entity 'SUPERIOR' named entity 'PANEL' named entity 'SPECIFICITIES' named entity 'ANTIGEN' named entity 'TEST' named entity 'IDENTIFIED' named entity 'WEEK' named entity 'specific' named entity 'individual' named entity 'tested' named entity 'antigen' named entity 'tests' named entity 'H1N1' named entity 'influenza A' named entity 'detection' named entity 'DFA' named entity 'superior' named entity 'test' named entity 'United States' named entity 'influenza' named entity 'H1N1 strain' named entity 'subtyping' named entity 'H1N1' named entity 'Virus' named entity 'diagnostic tests' named entity 'RT-PCR' named entity 'influenza' named entity 'H1N1' named entity 'antigen' named entity 'viruses' named entity 'NY City' named entity 'viral culture' named entity 'H1N1' named entity 'viruses' named entity 'CDC' named entity 'H1N1 infection' named entity 'Jewish' named entity 'United States' named entity 'Jewish' named entity 'Long Island' named entity 'high risk' named entity 'rhinovirus' named entity 'coronaviruses' named entity 'influenza' named entity 'New Hyde Park' named entity 'seasonal influenza' named entity 'NPV'

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