About: Identification of unique mutations in SARS-CoV-2 strains isolated from India suggests its attenuated pathotype

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of unique mutations in SARS-CoV-2 strains isolated from India suggests its attenuated pathotype
Creator	Kumar, Sachin Joshi, Chaitanya Joshi, Madhvi Gaurav, Shubham Pandey, Shambhavi Puvar, Apurvasinh Shah, Tejas
Source	BioRxiv
abstract	Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), which was first reported in Wuhan, China in November 2019 has developed into a pandemic since March 2020, causing substantial human casualties and economic losses. Studies on SARS-CoV-2 are being carried out at an unprecedented rate to tackle this threat. Genomics studies, in particular, are indispensable to elucidate the dynamic nature of the RNA genome of SARS-CoV-2. RNA viruses are marked by their unique ability to undergo high rates of mutation in their genome, much more frequently than their hosts, which diversifies their strengths qualifying them to elude host immune response and amplify drug resistance. In this study, we sequenced and analyzed the genomic information of the SARS-CoV-2 isolates from two infected Indian patients and explored the possible implications of point mutations in its biology. In addition to multiple point mutations, we found a remarkable similarity between relatively common mutations of 36-nucleotide deletion in ORF8 of SARS-CoV-2. Our results corroborate with the earlier reported 29-nucleotide deletion in SARS, which was frequent during the early stage of human-to-human transmission. The results will be useful to understand the biology of SARS-CoV-2 and itsattenuation for vaccine development.
has issue date	2020-06-07(xsd:dateTime)
bibo:doi	10.1101/2020.06.06.137604
has license	biorxiv
sha1sum (hex)	3284fb106e87806d76ea9f04381b1f9e191791a4
schema:url	https://doi.org/10.1101/2020.06.06.137604
resource representing a document's title	Identification of unique mutations in SARS-CoV-2 strains isolated from India suggests its attenuated pathotype
schema:publication	bioRxiv
resource representing a document's body	covid:3284fb106e87806d76ea9f04381b1f9e191791a4#body_text
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