About: Immunosuppression following surgical and traumatic injury

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Immunosuppression following surgical and traumatic injury Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunosuppression following surgical and traumatic injury
Creator	Kimura, Fumio Miyazaki, Masaru Ohtsuka, Masayuki Shimizu, Hiroaki Yoshidome, Hiroyuki
Source	PMC
abstract	Severe sepsis and organ failure are still the major causes of postoperative morbidity and mortality after major hepatobiliary pancreatic surgery. Despite recent progress in understanding the immune conditions of abdominal sepsis, the postoperative incidence of septic complications after major visceral surgery remains high. This review focuses on the clinical and immunological parameters that determine the risk of the development and lethal outcome of postoperative septic complication following major surgery and trauma. A review of the literature indicates that surgical and traumatic injury profoundly affects the innate and adaptive immune responses, and that a marked suppression in cell-mediated immunity following an excessive inflammatory response appears to be responsible for the increased susceptibility to subsequent sepsis. The innate and adaptive immune responses are initiated and modulated by pathogen-associated molecular-pattern molecules and by damage-associated molecular-pattern molecules through the pattern-recognition receptors. Suppression of cell-mediated immunity may be caused by multifaceted cytokine/inhibitor profiles in the circulation and other compartments of the host, excessive activation and dysregulated recruitment of polymorphonuclear neutrophils, induction of alternatively activated or regulatory macrophages that have anti-inflammatory properties, a shift in the T-helper (Th)1/Th2 balance toward Th2, appearance of regulatory T cells, which are potent suppressors of the innate and adaptive immune system, and lymphocyte apoptosis in patients with sepsis. Recent basic and clinical studies have elucidated the functional effects of surgical and traumatic injury on the immune system. The research studies of interest may in future aid in the selection of appropriate therapeutic protocols.
has issue date	2010-08-26(xsd:dateTime)
bibo:doi	10.1007/s00595-010-4323-z
bibo:pmid	20740341
has license	no-cc
sha1sum (hex)	32b80a7c580804ce09fa93937ccc4fd5e1b1b9b6
schema:url	https://doi.org/10.1007/s00595-010-4323-z
resource representing a document's title	Immunosuppression following surgical and traumatic injury
has PubMed Central identifier	PMC7101797
has PubMed identifier	20740341
schema:publication	Surg Today
resource representing a document's body	covid:32b80a7c580804ce09fa93937ccc4fd5e1b1b9b6#body_text
is schema:about of	named entity 'surgery' named entity 'caused' named entity 'functional' named entity 'RESEARCH STUDIES' named entity 'APPROPRIATE' named entity 'SELECTION' named entity 'SEPSIS' named entity 'POSTOPERATIVE' named entity 'CLINICAL' named entity 'LES' named entity 'MAJOR' named entity 'EXCESSIVE' named entity 'MODULATED' named entity 'PARAMETERS' named entity 'ASSOCIATED' named entity 'clinical studies' named entity 'excessive' named entity 'innate' named entity 'molecules' named entity 'Th2' named entity 'sepsis' named entity 'septic' named entity 'complication' named entity 'apoptosis' named entity 'adaptive immune responses' named entity 'adaptive immune responses' named entity 'apoptosis' named entity 'sepsis' named entity 'T-helper' named entity 'pancreatic surgery' named entity 'cytokine' named entity 'cell-mediated immunity' named entity 'regulatory T cells' named entity 'sepsis' named entity 'hepatobiliary' named entity 'trauma' named entity 'host' named entity 'osteoclasts' named entity 'pathogenesis' named entity 'sepsis' named entity 'single-stranded' named entity 'HLA-DR' named entity 'monocyte' named entity 'hypoperfusion' named entity 'IL-21' named entity 'caspase-1' named entity 'Pyrin domain' named entity 'vasodilatory' named entity 'adenosine' named entity 'surgical stress' named entity 'monocyte' named entity 'Tregs' named entity 'lung' named entity 'lymphocyte subsets' named entity 'Th17 cells' named entity 'lipopolysaccharide' named entity 'neutrophils' named entity 'IL-12' named entity 'sepsis' named entity 'Toll-like receptors' named entity 'P1 receptors' named entity 'interact' named entity 'pathogenesis' named entity 'TLRs' named entity 'Th17' named entity 'Circulating blood' named entity 'RIG-I' named entity 'pneumonia' named entity 'pancreatic surgery' named entity 'Crohn's disease' named entity 'antimicrobial peptides' named entity 'serum levels' named entity 'mononuclear cells' named entity 'monocyte' named entity 'HLA-DR' named entity 'sepsis' named entity 'IL-6'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software