About: Porcine deltacoronavirus (PDCoV) infection suppresses RIG-I-mediated interferon-β production

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About: Porcine deltacoronavirus (PDCoV) infection suppresses RIG-I-mediated interferon-β production Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Porcine deltacoronavirus (PDCoV) infection suppresses RIG-I-mediated interferon-β production
Creator	Chen, Huanchun Fang, Liurong Wang, Dang Xiao, Shaobo Ding, Zhen Dong, Nan Fang, Puxian Luo, Jingyi
Source	Elsevier; Medline; PMC
abstract	Abstract Porcine deltacoronavirus (PDCoV), an emerging animal coronavirus causing enteric disease in pigs, belongs to the newly identified Deltacoronavirus genus in the Coronaviridae family. Although extensive studies have been carried out to investigate the regulation of interferon (IFN) responses by alphacoronaviruses, betacoronaviruses, and gammacoronaviruses, little is known about this process during deltacoronavirus infection. In this study, we found that PDCoV infection fails to induce, and even remarkably inhibits, Sendai virus- or poly(I: C)-induced IFN-β production by impeding the activation of transcription factors NF-κB and IRF3. We also found that PDCoV infection significantly suppresses the activation of IFN-β promoter stimulated by IRF3 or its upstream molecules (RIG-I, MDA5, IPS-1, TBK1, IKKε) in the RIG-I signaling pathway, but does not counteract its activation by the constitutively active mutant of IRF3 (IRF3–5D). Taken together, our results demonstrate that PDCoV infection suppresses RIG-I-mediated IFN signaling pathway, providing a better understanding of the PDCoV immune evasion strategy.
has issue date	2016-08-31(xsd:dateTime)
bibo:doi	10.1016/j.virol.2016.04.025
bibo:pmid	27152478
has license	els-covid
sha1sum (hex)	3301a21965d77cb118b0540783328ca1a4ed6cc5
schema:url	https://doi.org/10.1016/j.virol.2016.04.025
resource representing a document's title	Porcine deltacoronavirus (PDCoV) infection suppresses RIG-I-mediated interferon-β production
has PubMed Central identifier	PMC7111668
has PubMed identifier	27152478
schema:publication	Virology
resource representing a document's body	covid:3301a21965d77cb118b0540783328ca1a4ed6cc5#body_text
is schema:about of	named entity 'NF-κB' named entity 'infection' named entity 'responses' named entity 'infection' named entity 'activation' named entity 'pigs' named entity 'Coronaviridae' named entity 'disease' named entity 'Sendai' named entity 'interferon' named entity 'MEDIATED' named entity 'TO INVESTIGATE' named entity 'RESPONSES' named entity 'STIMULATED' named entity 'CORONAVIRIDAE' named entity 'PROMOTER' named entity 'BETTER' named entity 'INFECTION' named entity 'PRODUCTION' named entity 'IDENTIFIED' named entity 'STUDY' named entity 'ANIMAL' named entity 'FOUND' named entity 'OUR' named entity 'TRANSCRIPTION FACTORS' named entity 'LITTLE' named entity 'ENTERIC' named entity 'FAMILY' named entity 'CONSTITUTIVELY ACTIVE' named entity 'HAVE' named entity 'INTERFERON ' named entity 'IFN' named entity 'DISEASE' named entity 'NEWLY' named entity 'ITS' named entity 'GENUS' named entity 'BETACORONAVIRUSES' named entity 'EXTENSIVE' named entity 'RIG-I' named entity 'SUPPRESSES' named entity 'INTERFERON' named entity 'MEDIATED' named entity 'RESULTS' named entity 'SIGNALING PATHWAY' named entity 'ACTIVATION' named entity 'SUPPRESSES' named entity 'SENDAI VIRUS' named entity 'CORONAVIRUS' named entity 'UPSTREAM' named entity 'RIG-I SIGNALING PATHWAY' named entity 'REGULATION' named entity 'CAUSING' named entity 'MUTANT' named entity 'INDUCED' named entity 'MOLECULES' named entity 'KNOWN' named entity 'IMMUNE EVASION' named entity 'MDA5' named entity 'IKK' named entity 'IMPEDING' named entity 'ABOUT' named entity 'PIGS' named entity 'PRODUCTION' named entity '28I' named entity 'PROVIDING' named entity 'PORCINE DELTACORONAVIRUS' named entity 'POLY' named entity 'DOES NOT' named entity 'UNDERSTANDING' named entity 'PROCESS' named entity 'RIG-I' named entity 'DELTACORONAVIRUS' named entity 'FAILS' named entity 'IRF3'

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