About: Clinical remission of a critically ill COVID-19 patient treated by human umbilical cord mesenchymal stem cells: A case report

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About: Clinical remission of a critically ill COVID-19 patient treated by human umbilical cord mesenchymal stem cells: A case report Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical remission of a critically ill COVID-19 patient treated by human umbilical cord mesenchymal stem cells: A case report
Creator	Li, Tao Li, Yang Yang, Wenjie Hu, Min Li, Chen Li, Jianchun Qian, Chuanyun Li, Y Chen, Junhui Gao, Yanfeng Liang, B Li, Yanjiao Liang, Bing Ma, Zhaoxia Nie, Fangang Nie, Panrong Wu, Haiying Xiao, Mingying Yang, Mingxi Yu, Congtao
Source	Medline; PMC
abstract	RATIONALE: The COVID-19 cases increased very fast in January and February 2020. The mortality among critically ill patients, especially the elder ones, is relatively high. Considering many patients died of severe inflammation response, it is urgent to develop effective therapeutic strategies for these patients. The human umbilical cord mesenchymal stem cells (hUCMSCs) have shown good capabilities to modulate the immune response and repair the injured tissue. Therefore, investigating the potential of hUCMSCs to the treatment of COVID-19 critically ill patients is necessary. PATIENT CONCERNS: A 65-year-old woman felt fatigued and had a fever with body temperature of 38.2(°)C, coughed up white foaming sputum. After 1 day, she had chest tightness with SPO(2) of 81%, and blood pressure of 160/91 mm Hg. DIAGNOSE: According to the guideline for the diagnosis and treatment of 2019 novel coronavirus infected pneumonia (Trial 4th Edition), COVID-19 was diagnosed, based on the real-time RT-PCR test of SARS-CoV-2. INTERVENTIONS: After regular treatment for 12 days, the inflammation symptom of the patient was still very severe and the potential side effects of corticosteroid were observed. Then, allogenic hUCMSCs were given 3 times (5 × 10(7) cells each time) with a 3-day interval, together with thymosin α1 and antibiotics daily injection. OUTCOMES: After these treatments, most of the laboratory indexes and CT images showed remission of the inflammation symptom. The patient was subsequently transferred out of ICU, and the throat swabs test reported negative 4 days later. LESSONS: These results indicated the clinical outcome and good tolerance of allogenic hUCMSCs transfer.
has issue date	2020-07-31(xsd:dateTime)
bibo:doi	10.1097/md.0000000000021429
bibo:pmid	32756149
has license	cc-by
sha1sum (hex)	337170ca726db91731666512d08b37a0e05fb8ca
schema:url	https://doi.org/10.1097/md.0000000000021429
resource representing a document's title	Clinical remission of a critically ill COVID-19 patient treated by human umbilical cord mesenchymal stem cells: A case report
has PubMed Central identifier	PMC7402800
has PubMed identifier	32756149
schema:publication	Medicine (Baltimore)
resource representing a document's body	covid:337170ca726db91731666512d08b37a0e05fb8ca#body_text
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