About: Hemorrhagic Fever-Causing Arenaviruses: Lethal Pathogens and Potent Immune Suppressors

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Hemorrhagic Fever-Causing Arenaviruses: Lethal Pathogens and Potent Immune Suppressors
Creator	Ly, Hinh Koma, Takaaki Padhan, Kartika Brisse, Morgan
source	PMC
abstract	Hemorrhagic fevers (HF) resulting from pathogenic arenaviral infections have traditionally been neglected as tropical diseases primarily affecting African and South American regions. There are currently no FDA-approved vaccines for arenaviruses, and treatments have been limited to supportive therapy and use of non-specific nucleoside analogs, such as Ribavirin. Outbreaks of arenaviral infections have been limited to certain geographic areas that are endemic but known cases of exportation of arenaviruses from endemic regions and socioeconomic challenges for local control of rodent reservoirs raise serious concerns about the potential for larger outbreaks in the future. This review synthesizes current knowledge about arenaviral evolution, ecology, transmission patterns, life cycle, modulation of host immunity, disease pathogenesis, as well as discusses recent development of preventative and therapeutic pursuits against this group of deadly viral pathogens.
has issue date	2019-03-13(xsd:dateTime)
bibo:doi	10.3389/fimmu.2019.00372
bibo:pmid	30918506
has license	cc-by
sha1sum (hex)	3380d0cb8447aa4741878f8a3d300a3765ed9a40
schema:url	https://doi.org/10.3389/fimmu.2019.00372
resource representing a document's title	Hemorrhagic Fever-Causing Arenaviruses: Lethal Pathogens and Potent Immune Suppressors
has PubMed Central identifier	PMC6424867
has PubMed identifier	30918506
schema:publication	Front Immunol
resource representing a document's body	covid:3380d0cb8447aa4741878f8a3d300a3765ed9a40#body_text
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