About: CD4(+) T-Cell Expansion Predicts Neutralizing Antibody Responses to Monovalent, Inactivated 2009 Pandemic Influenza A(H1N1) Virus Subtype H1N1 Vaccine

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About: CD4(+) T-Cell Expansion Predicts Neutralizing Antibody Responses to Monovalent, Inactivated 2009 Pandemic Influenza A(H1N1) Virus Subtype H1N1 Vaccine Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	CD4(+) T-Cell Expansion Predicts Neutralizing Antibody Responses to Monovalent, Inactivated 2009 Pandemic Influenza A(H1N1) Virus Subtype H1N1 Vaccine
Creator	Treanor, John Yang, Hongmei Sant, Andrea Fitzgerald, Theresa Nayak, Jennifer Richards, Katherine
Source	PMC
abstract	Background. The ability of influenza vaccines to elicit CD4(+) T cells and the relationship between induction of CD4(+) T cells and vaccine-induced neutralizing antibody responses has been controversial. The emergence of swine-origin 2009 pandemic influenza A virus subtype H1N1 (A[H1N1]pdm09) provided a unique opportunity to examine responses to an influenza vaccine composed of both novel and previously encountered antigens and to probe the relationship between B-cell and T-cell responses to vaccination. Methods. We tracked CD4(+) T-cell and antibody responses of human subjects vaccinated with monovalent subunit A(H1N1)pdm09 vaccine. The specificity and magnitude of the CD4(+) T-cell response was evaluated using cytokine enzyme-linked immunosorbent spot assays in conjugation with peptide pools representing distinct influenza virus proteins. Results. Our studies revealed that vaccination induced readily detectable CD4(+) T cells specific for conserved portions of hemagglutinin (HA) and the internal viral proteins. Interestingly, expansion of HA-specific CD4(+) T cells was most tightly correlated with the antibody response. Conclusions. These results indicate that CD4(+) T-cell expansion may be a limiting factor in development of neutralizing antibody responses to pandemic influenza vaccines and suggest that approaches to facilitate CD4(+) T-cell recruitment may increase the neutralizing antibody produced in response to vaccines against novel influenza strains.
has issue date	2013-01-15(xsd:dateTime)
bibo:doi	10.1093/infdis/jis684
bibo:pmid	23148285
has license	no-cc
sha1sum (hex)	33a8980d8afda0140d74e92374c2deab725f019e
schema:url	https://doi.org/10.1093/infdis/jis684
resource representing a document's title	CD4(+) T-Cell Expansion Predicts Neutralizing Antibody Responses to Monovalent, Inactivated 2009 Pandemic Influenza A(H1N1) Virus Subtype H1N1 Vaccine
has PubMed Central identifier	PMC3532833
has PubMed identifier	23148285
schema:publication	J Infect Dis
resource representing a document's body	covid:33a8980d8afda0140d74e92374c2deab725f019e#body_text
is schema:about of	named entity 'H1N1' named entity 'Inactivated' named entity 'Virus' named entity 'B-CELL' named entity 'Background' named entity 'B-cell' named entity 'T cells' named entity 'neutralizing antibody' named entity 'vaccine' named entity 'tetanus toxoid' named entity 'CD4 +' named entity 'CD4 +' named entity 'peptide' named entity 'neutralizing antibody' named entity 'composed' named entity '2009' named entity 'H1N1' named entity 'T-cell' named entity 'influenza vaccine' named entity 'CD4 +' named entity 'influenza A virus subtype H1N1' named entity 'swine' named entity 'Monovalent' named entity 'Pandemic Influenza' named entity 'Virus' named entity 'Neutralizing Antibody' named entity 'CD4 +' named entity 'CD4 +' named entity 'antigen' named entity 'egg allergy' named entity 'CD4 +' named entity 'live attenuated influenza vaccine' named entity 'influenza vaccination' named entity 'interferon γ' named entity 'cross-reactive' named entity 'titer' named entity 'T-cell' named entity 'B-cell' named entity 'antibody' named entity 'influenza virus' named entity 'antibody' named entity 'titer' named entity 'neutralizing antibody' named entity 'class II' named entity 'T-cell' named entity 'median age' named entity 'CD4 +' named entity 'vaccination' named entity 'CD8 +' named entity 'influenza' named entity 'extrafollicular' named entity 'antibody titer' named entity 'effector' named entity 'CD4 +' named entity 'CD4 +' named entity 'antigen' named entity 'microtiter' named entity 'CD4 +' named entity 'pandemic influenza' named entity 'antigen presentation' named entity 'peptides' named entity 'body mass index' named entity 'statistical significance' named entity 'epitopes' named entity 'immunosuppression' named entity 'lymph node' named entity 'neutralizing antibodies' named entity 'neutralizing antibody' named entity 'antigens' named entity 'titer' named entity 'epitopes' named entity 'antibody response' named entity 'California' named entity 'peptide' named entity 'T-cell' named entity 'T-cell'

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