About: Developing Novel G-Quadruplex Ligands: From Interaction with Nucleic Acids to Interfering with Nucleic Acid

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Developing Novel G-Quadruplex Ligands: From Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein Interaction Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Developing Novel G-Quadruplex Ligands: From Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein Interaction
Creator	Cheng, Sui-Qi Ou, Tian-Miao Su, Xiao-Xuan Sun, Zhi-Yin Wang, Xiao-Na
source	Medline; PMC
abstract	G-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of genome. G-quadruplexes have been proved to be involved in the regulation of replication, DNA damage repair, and transcription and translation of oncogenes or other cancer-related genes. Therefore, targeting G-quadruplexes has become a novel promising anti-tumor strategy. Different kinds of small molecules targeting the G-quadruplexes have been designed, synthesized, and identified as potential anti-tumor agents, including molecules directly bind to the G-quadruplex and molecules interfering with the binding between the G-quadruplex structures and related binding proteins. This review will explore the feasibility of G-quadruplex ligands acting as anti-tumor drugs, from basis to application. Meanwhile, since helicase is the most well-defined G-quadruplex-related protein, the most extensive research on the relationship between helicase and G-quadruplexes, and its meaning in drug design, is emphasized.
has issue date	2019-01-22(xsd:dateTime)
bibo:doi	10.3390/molecules24030396
bibo:pmid	30678288
has license	cc-by
sha1sum (hex)	33cf03ea72e45ea6d6beeccc91c5145807544728
schema:url	https://doi.org/10.3390/molecules24030396
resource representing a document's title	Developing Novel G-Quadruplex Ligands: From Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein Interaction
has PubMed Central identifier	PMC6384609
has PubMed identifier	30678288
schema:publication	Molecules
resource representing a document's body	covid:33cf03ea72e45ea6d6beeccc91c5145807544728#body_text
is schema:about of	named entity 'NUCLEIC ACID' named entity 'well-defined' named entity 'involved' named entity 'anti-tumor' named entity 'genes' »more»

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software