About: Discovery of a Bovine Enterovirus in Alpaca

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Discovery of a Bovine Enterovirus in Alpaca
Creator	Borst, L Fredrickson, R Krause, P Mcclenahan, S Scherba, G
Source	Medline; PMC
abstract	A cytopathic virus was isolated using Madin-Darby bovine kidney (MDBK) cells from lung tissue of alpaca that died of a severe respiratory infection. To identify the virus, the infected cell culture supernatant was enriched for virus particles and a generic, PCR-based method was used to amplify potential viral sequences. Genomic sequence data of the alpaca isolate was obtained and compared with sequences of known viruses. The new alpaca virus sequence was most similar to recently designated Enterovirus species F, previously bovine enterovirus (BEVs), viruses that are globally prevalent in cattle, although they appear not to cause significant disease. Because bovine enteroviruses have not been previously reported in U.S. alpaca, we suspect that this type of infection is fairly rare, and in this case appeared not to spread beyond the original outbreak. The capsid sequence of the detected virus had greatest homology to Enterovirus F type 1 (indicating that the virus should be considered a member of serotype 1), but the virus had greater homology in 2A protease sequence to type 3, suggesting that it may have been a recombinant. Identifying pathogens that infect a new host species for the first time can be challenging. As the disease in a new host species may be quite different from that in the original or natural host, the pathogen may not be suspected based on the clinical presentation, delaying diagnosis. Although this virus replicated in MDBK cells, existing standard culture and molecular methods could not identify it. In this case, a highly sensitive generic PCR-based pathogen-detection method was used to identify this pathogen.
has issue date	2013-08-12(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0068777
bibo:pmid	23950875
has license	cc0
sha1sum (hex)	33ea5a062d23a8c46b7d6e9ba23f1c82f40fde29
schema:url	https://doi.org/10.1371/journal.pone.0068777
resource representing a document's title	Discovery of a Bovine Enterovirus in Alpaca
has PubMed Central identifier	PMC3741315
has PubMed identifier	23950875
schema:publication	PLoS One
resource representing a document's body	covid:33ea5a062d23a8c46b7d6e9ba23f1c82f40fde29#body_text
is schema:about of	covid:arg/33ea5a062d23a8c46b7d6e9ba23f1c82f40fde29 named entity 'virus' named entity 'host species' named entity 'lung tissue' named entity 'pathogen' named entity 'pathogens' named entity 'supernatant' named entity 'kidney' named entity 'type 1' named entity 'bovine' named entity 'bovine' named entity 'host species' named entity 'protease' named entity 'molecular methods' named entity 'viruses' named entity 'Enterovirus' named entity 'alpaca' named entity 'enteroviruses' named entity 'Enterovirus' named entity 'pathogen' named entity 'infection' named entity 'South America' named entity 'alpaca' named entity 'habitat' named entity 'llama' named entity 'housekeeping genes' named entity 'NCBI' named entity 'Foster City' named entity 'viruses' named entity 'bovine' named entity 'host species' named entity 'cytopathic' named entity 'serotypes' named entity 'electron microscopy' named entity 'viruses' named entity 'enterovirus' named entity 'alpaca' named entity 'Bethesda, MD' named entity 'polypeptide' named entity 'enteroviruses' named entity 'supernatant' named entity 'farm animals' named entity 'capped langur' named entity 'PCR' named entity 'bovine viral diarrhea virus' named entity 'cell culture' named entity 'homology' named entity 'pathogenicity' named entity 'alpaca' named entity 'kidney' named entity 'alpaca' named entity 'PCR-based' named entity 'gene' named entity 'lungs' named entity 'viruses' named entity 'PCR' named entity 'enteroviruses' named entity 'nucleic acid' named entity 'infection' named entity 'Clustal' named entity 'viruses' named entity 'alpaca' named entity 'homology' named entity 'bluetongue virus' named entity 'PCR' named entity 'capsid protein' named entity 'homologous' named entity 'vector' named entity 'untranslated region' named entity 'South American' named entity 'livestock' named entity 'serotypes' named entity 'capsid' named entity 'alpaca' named entity 'ammonium molybdate' named entity 'vicuna' named entity 'MMLV'

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