About: The HSP72 stress response of monocytes from patients on haemodialysis is impaired

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About: The HSP72 stress response of monocytes from patients on haemodialysis is impaired Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The HSP72 stress response of monocytes from patients on haemodialysis is impaired
Creator	Pavenstädt, Hermann Bangen, Philip Edemir, Bayram Heidenreich, Stefan Hillebrand, Uta Lang, Detlef Reuter, Stefan
Source	PMC
abstract	Background. Induction of heat shock proteins (HSP), i.e. of the major family member HSP70, is an important cytoprotective-resistance mechanism for monocytes/ macrophages (Mphi). Patients on haemodialysis present with a high infectious morbidity and enhanced carcinoma incidence. Renal insufficiency-related alteration of microbicidal and tumoricidal functions of Mphi, major effectors of the immune system, might promote these diseases. Methods. Freshly isolated Mphi from Sprague–Dawley rats 2 weeks after 5/6-nephrectomy and from patients on intermittent haemodialysis (IHD) were stimulated by heat shock (HS) and compared to stimulated Mphi of control rats or healthy volunteers (CTR). Expression of HSP72 (inducible HSP70) was assessed by RT-PCR, and/or flow cytometry. Apoptosis of Mphi was detected by flow cytometry (CD14/annexin V-labelling). Results. In rat Mphi, baseline HSP72 expression was similar in both groups, but its induction was significantly impaired in renal insufficiency (214 ± 68% less HSP70-mRNA versus CTR, n = 6). In patients, HSF-1-mRNA and HSP72-mRNA/protein response to HS was significantly lower, but not affected by dialysis session itself. In parallel, apoptosis of Mphi of patients was enhanced (+83 ± 29% constitutive apoptotic Mphi versus CTR, n = 8), and HS-dependent protection from apoptosis with and without serum depletion (48 h depletion: HS, +275 ± 37% apoptotic Mphi versus CTR, n = 6; full medium: +166 ± 62% versus CTR, n = 8, P < 0.05) was inferior. Conclusions. Impaired HSP72 stress response of Mphi in patients on haemodialysis might contribute to the observed immune dysfunction and, therefore, to the increased susceptibility to infection and malignancy. Stress impairment is not restricted to uraemia but is already present in a rat model of chronic kidney disease.
has issue date	2009-04-01(xsd:dateTime)
bibo:doi	10.1093/ndt/gfp142
bibo:pmid	19339340
has license	no-cc
sha1sum (hex)	33f925c0d9eb1e4697a12d38f8892c06186b868b
schema:url	https://doi.org/10.1093/ndt/gfp142
resource representing a document's title	The HSP72 stress response of monocytes from patients on haemodialysis is impaired
has PubMed Central identifier	PMC7107957
has PubMed identifier	19339340
schema:publication	Nephrol Dial Transplant
resource representing a document's body	covid:33f925c0d9eb1e4697a12d38f8892c06186b868b#body_text
is schema:about of	named entity 'effectors' named entity 'mRNA' named entity 'haemodialysis' named entity 'expression' named entity 'high' named entity 'HSP72' named entity 'IMPAIRED' named entity 'IMPORTANT' named entity 'RESPONSE TO' named entity 'INDUCTION' named entity 'RATS' named entity 'HEAT SHOCK PROTEINS' named entity 'LABELLING' named entity 'CYTOPROTECTIVE' named entity 'CONTRIBUTE ' named entity 'INTERMITTENT HAEMODIALYSIS' covid:arg/33f925c0d9eb1e4697a12d38f8892c06186b868b named entity 'RELATED' named entity 'PATIENTS' named entity 'MORBIDITY' named entity 'APOPTOSIS' named entity 'HIGH' named entity 'HSP70' named entity 'IMPAIRED' named entity 'RESISTANCE MECHANISM' named entity 'APOPTOTIC' named entity 'STRESS RESPONSE' named entity 'RT-PCR' named entity 'DETECTED' named entity 'SERUM' named entity 'ALTERATION' named entity 'HAEMODIALYSIS' named entity 'MONOCYTES' named entity 'HAEMODIALYSIS' named entity 'CARCINOMA' named entity 'RESTRICTED' named entity 'STRESS' named entity 'METHODS' named entity 'FAMILY MEMBER' named entity 'DISEASES' named entity 'SPRAGUE-DAWLEY RATS' named entity 'STRESS RESPONSE' named entity 'HSP72' named entity 'HEAT SHOCK' named entity 'EXPRESSION' named entity 'MODEL OF' named entity 'CONCLUSIONS' named entity '2 WEEKS' named entity 'MALIGNANCY' named entity 'PRESENT' named entity 'PROTECTION' named entity 'RENAL INSUFFICIENCY' named entity 'STIMULATED' named entity 'DIALYSIS' named entity 'SESSION' named entity 'MAJOR' named entity 'SIMILAR' named entity 'MPHI' named entity 'BASELINE' named entity '0.05' named entity 'LOWER' named entity 'MACROPHAGES' named entity 'BUT' named entity 'HS-' named entity 'ISOLATED' named entity 'IMMUNE DYSFUNCTION' named entity 'MEDIUM' named entity 'FUNCTIONS' named entity 'MONOCYTES' named entity 'HSF-1' named entity 'DEPENDENT' named entity 'CTR' named entity 'MRNA' named entity 'THESE' named entity 'INCIDENCE'

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