About: Serological evidence of MERS-CoV and HKU8-related CoV co-infection in Kenyan camels

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About: Serological evidence of MERS-CoV and HKU8-related CoV co-infection in Kenyan camels Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Serological evidence of MERS-CoV and HKU8-related CoV co-infection in Kenyan camels
Creator	Wang, Ning Chen, Jing Wang, Lin-Fa Zhu, Yan Shi, Zheng-Li Zhang, Wei Li, Bei Mani, Shailendra Yang, Xing-Lou Zheng, Xiao-Shuang Zhou, Peng Zhao, Kai Agwanda, Bernard Hu, Ben Ommeh, Sheila Yan, Bing Lichoti, Jacqueline Ngeiywa, Kisa-Juma Anderson, Danielle Onyuok, Samson
Source	Medline; PMC
abstract	Dromedary camels are important reservoir hosts of various coronaviruses, including Middle East respiratory syndrome coronavirus (MERS-CoV) that cause human infections. CoV genomes regularly undergo recombination during infection as observed in bat SARS-related CoVs. Here we report for the first time that only a small proportion of MERS-CoV receptor-binding domain positive (RBD) of spike protein positive camel sera in Kenya were also seropositive to MERS-CoV nucleocapsid (NP). In contrast, many of them contain antibodies against bat HKU8-related (HKU8r)-CoVs. Among 584 camel samples that were positive against MERS-CoV RBD, we found only 0.48 (8.22%) samples were also positive for NP. Furthermore, we found bat HKU8r-CoV NP antibody in 73 (12.5%) of the MERS-CoV RBD positive and NP negative samples, yet found only 3 (0.43%) of the HKU8r-CoV S1 antibody in the same samples. These findings may indicate co-infection with MERS-CoV and a HKU8r-CoV in camels. It may also raise the possibility of the circulation of a recombinant coronavirus virus with the spike of MERS-CoV and the NP of a HKU8r-CoV in Kenya. We failed to find molecular evidence of an HKU8r-CoV or a putative recombinant virus. Our findings should alert other investigators to look for molecular evidence of HKU8r-CoV or recombinants.
has issue date	2019-10-24(xsd:dateTime)
bibo:doi	10.1080/22221751.2019.1679610
bibo:pmid	31645223
has license	cc-by
sha1sum (hex)	33fbcefc12a3f06bf2e20b88ac1b69d481746250
schema:url	https://doi.org/10.1080/22221751.2019.1679610
resource representing a document's title	Serological evidence of MERS-CoV and HKU8-related CoV co-infection in Kenyan camels
has PubMed Central identifier	PMC6818114
has PubMed identifier	31645223
schema:publication	Emerg Microbes Infect
resource representing a document's body	covid:33fbcefc12a3f06bf2e20b88ac1b69d481746250#body_text
is schema:about of	named entity 'SEROLOGICAL' named entity 'camel' named entity 'circulation' named entity 'reservoir' named entity 'molecular' named entity 'protein' named entity 'samples' named entity 'evidence' named entity 'EVIDENCE OF' named entity 'FOUND' named entity 'PROTEIN ' named entity 'SPIKE PROTEIN' named entity 'SARS' named entity 'CORONAVIRUS' named entity 'GENOMES' named entity 'RECOMBINANT VIRUS' named entity 'TIME' named entity 'HUMAN' named entity 'RESERVOIR' named entity 'BAT' named entity 'CO-INFECTION' named entity 'CAMELS' named entity 'ALERT' named entity 'INCLUDING' named entity 'BINDING' named entity 'ANTIBODY' named entity 'RBD' named entity 'SPIKE' named entity 'NUCLEOCAPSID' named entity 'RECOMBINANTS' named entity 'CAMEL' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'FINDINGS' named entity 'SEROPOSITIVE' named entity 'CIRCULATION' named entity 'INFECTIONS' named entity 'DOMAIN' named entity 'RECOMBINATION' named entity 'SERA' named entity '584' named entity '0.48' named entity 'IMPORTANT' named entity 'LOOK' named entity 'FAILED' named entity 'RECOMBINANT' named entity 'KENYA' named entity 'VIRUS' named entity 'VARIOUS' named entity 'CO-INFECTION' named entity 'COVS' named entity 'INVESTIGATORS' covid:arg/33fbcefc12a3f06bf2e20b88ac1b69d481746250 named entity 'PROPORTION' named entity 'EVIDENCE OF' named entity 'RELATED' named entity 'RELATED' named entity 'RECEPTOR' named entity 'CONTRAST' named entity 'SAMPLES' named entity 'CAMELS' named entity 'HOSTS' named entity 'POSITIVE'

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