About: Intraventricular Tigecycline as a Last Resort Therapy in a Patient with Difficult-to-Treat Healthcare-Associated Acinetobacter baumannii Ventriculitis: a Case Report

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About: Intraventricular Tigecycline as a Last Resort Therapy in a Patient with Difficult-to-Treat Healthcare-Associated Acinetobacter baumannii Ventriculitis: a Case Report Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Intraventricular Tigecycline as a Last Resort Therapy in a Patient with Difficult-to-Treat Healthcare-Associated Acinetobacter baumannii Ventriculitis: a Case Report
Creator	Abdallah, Mohammad Alfawares, Reem Alobaid, Abdulaziz Alsaleh, Hamzeh Baradwan, Abdallah Rasheed, Akram Soliman, Ibrahim
source	PMC
abstract	Healthcare-associated ventriculitis and meningitis is a common complication in patients who suffer from head trauma or have undergone a neurosurgery. Healthcare-associated ventriculitis and meningitis is associated with significant morbidity and mortality. Complications of healthcare-associated ventriculitis and meningitis include persistent vegetative state, moderate and severe disability, and death. Acinetobacter baumannii is the causative pathogen in 3.6–11.2% of cases of healthcare-associated ventriculitis and meningitis. Cases of difficult-to-treat healthcare-associated A. baumannii ventriculitis and meningitis are being reported more frequently. However, in most of these cases, a combination of intravenous (IV) and intraventricular (IVT)/intrathecal colistin achieves good therapeutic outcome. This report describes a clinical case of difficult-to-treat healthcare-associated A. baumannii ventriculitis. The A. baumannii strain was sensitive to colistin and trimethoprim-sulfamethoxazole, intermediate to tigecycline, and resistant to other antibiotics. While colistin was the drug of choice in our case, the patient developed anaphylactoid reaction during the IV administration of the loading dose of colistin, which mandated us to discontinue colistin and complicated the treatment of our patient. The patient did not respond to a combination of IV antibiotics that included meropenem, trimethoprim-sulfamethoxazole, and tigecycline. However, when IVT tigecycline was added as a last-resort therapeutic option, the patient’s ventriculitis dramatically improved, and the patient was discharged from the hospital. Physicians who treat patients with healthcare-associated A. baumannii ventriculitis might resort to IVT tigecycline when they run out of therapeutic options.
has issue date	2020-08-09(xsd:dateTime)
bibo:doi	10.1007/s42399-020-00433-7
has license	no-cc
sha1sum (hex)	340649206b935ae88eab80a3c60b689233f8992d
schema:url	https://doi.org/10.1007/s42399-020-00433-7
resource representing a document's title	Intraventricular Tigecycline as a Last Resort Therapy in a Patient with Difficult-to-Treat Healthcare-Associated Acinetobacter baumannii Ventriculitis: a Case Report
has PubMed Central identifier	PMC7415013
schema:publication	SN Compr Clin Med
resource representing a document's body	covid:340649206b935ae88eab80a3c60b689233f8992d#body_text
is schema:about of	named entity 'Acinetobacter baumannii' named entity 'treat' named entity 'strain' named entity 'vegetative' named entity 'meningitis' named entity 'disability' named entity 'patient' named entity 'common' named entity 'complication' named entity 'meningitis' named entity 'COLISTIN' named entity 'CASES' named entity 'ACINETOBACTER BAUMANNII' named entity 'GOOD' named entity 'STRAIN' named entity 'REPORTED' named entity '11.2' named entity '3.6' named entity 'DEATH' named entity 'meropenem' named entity 'This' named entity 'sensitive' named entity 'choice' named entity 'Physicians' named entity 'mortality' named entity 'intraventricular' named entity 'describes' named entity 'tigecycline' named entity 'patient' named entity 'trimethoprim-sulfamethoxazole' named entity 'combination' named entity 'healthcare-associated' named entity 'intrathecal' named entity 'Complications' named entity 'therapeutic' named entity 'colistin' named entity 'pathogen' named entity 'meningitis' named entity 'meningitis' named entity 'A. baumannii' named entity 'colistin' named entity 'last-resort' named entity 'trimethoprim-sulfamethoxazole' named entity 'intraventricular' named entity 'treat patients' named entity 'meningitis' named entity 'trimethoprim-sulfamethoxazole' named entity 'Acinetobacter baumannii' named entity 'IV administration' named entity 'persistent vegetative state' named entity 'A. baumannii' named entity 'healthcare-associated' named entity 'ventriculitis' named entity 'head trauma' named entity 'ventriculitis' named entity 'resistant to other antibiotics' named entity 'colistin' named entity 'Acinetobacter baumannii' named entity 'colistin' named entity 'trimethoprim-sulfamethoxazole' named entity 'colistin' named entity 'seizures' named entity 'tachycardia' named entity 'meningitis' named entity 'IVT' named entity 'glucose' named entity 'tigecycline' named entity 'CSF analysis' named entity 'hemorrhagic' named entity 'ventriculitis' named entity 'loading dose' named entity 'colistin' named entity 'King Saud Medical City' named entity 'EVD' named entity 'neurology' named entity 'EVD' named entity 'bacterial growth'

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