About: Partial recovery of disturbed V-J pairing profiles of T-cell receptor in people living with HIV receiving long-term antiretroviral therapy

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About: Partial recovery of disturbed V-J pairing profiles of T-cell receptor in people living with HIV receiving long-term antiretroviral therapy Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Partial recovery of disturbed V-J pairing profiles of T-cell receptor in people living with HIV receiving long-term antiretroviral therapy
Creator	Chen, Chen Li, Bei Liu, Di Zhang, Yu Hao, Yu Zhang, J Li, Jiarui Li, Rui Liu, Y Zeng, Hui Du, Juan Zhao, Hongxin Zhang, H Zhang, Fujie Li, Guoli Li, G Han, Junyan Song, Chuan Zeng, L Zeng, Yongqin Zhang, Henghui Zhu, Liuluan
source	PMC
abstract	Chronic human immunodeficiency virus (HIV) infection not only causes a gradual loss of CD4(+) T cells but also leads to a disturbance of the T cell receptor (TCR) repertoire. In people living with HIV (PLWH), monitoring TCR repertoire is challenged by the inconsistency of complementarity determining region 3 (CDR3) and limited cell numbers in clinical samples. Thus, a quantitative method is necessary for monitoring the TCR repertoire in PLWH. We characterized the TCR V-J pairing profile of naïve and memory CD4(+) T cells in healthy donors, HIV-infected antiretroviral therapy (ART)-naïve patients and long-term (over 5 years) ART-experienced patients by performing TCR sequencing. We developed a V-J index with 18 parameters which were subdivided into five categories (expression coverage, cumulative percentage of the top tenth percentile, diversity, intra-individual similarity and inter-individual similarity). In ART-naïve patients, 14 of the 18 parameters were significantly altered. Long-term ART recovered ten parameters. The four unrecovered parameters were related to inter-individual similarity. Therefore, these findings indicate that long-term ART could only partially recover TCR V-J pairs and introduce newly impacted V-J pairs. Moreover, these results provide new insights into the V-J pairing of the TCR and into the disturbance of TCR repertoire in HIV infection. ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s11427-020-1718-2 and is accessible for authorized users.
has issue date	2020-06-18(xsd:dateTime)
bibo:doi	10.1007/s11427-020-1718-2
has license	no-cc
sha1sum (hex)	343b7c9e9ed4464098af404c7f22d39bb40af6e9
schema:url	https://doi.org/10.1007/s11427-020-1718-2
resource representing a document's title	Partial recovery of disturbed V-J pairing profiles of T-cell receptor in people living with HIV receiving long-term antiretroviral therapy
has PubMed Central identifier	PMC7306449
schema:publication	Sci China Life Sci
resource representing a document's body	covid:343b7c9e9ed4464098af404c7f22d39bb40af6e9#body_text
is schema:about of	named entity 'receiving' named entity 'patients' named entity 'T cell' named entity 'TCR' named entity 'receptor' named entity 'similarity' named entity 'living' named entity 'TCR' named entity 'antiretroviral therapy' named entity 'IMPACTED' named entity 'ART' named entity 'RESULTS' named entity 'PEOPLE' named entity 'T CELL RECEPTOR' named entity 'CATEGORIES' named entity 'HIV INFECTION' named entity 'CHINA' named entity 'TCR' named entity 'INSIGHTS' named entity 'ANTIRETROVIRAL THERAPY' named entity 'LIMITED' named entity 'NEW' named entity 'SCI' named entity 'DIVERSITY' named entity 'PARAMETERS' named entity 'LEADS' named entity 'T-CELL RECEPTOR' named entity 'SUBDIVIDED' named entity 'cell' named entity 'samples' named entity 'pairs' named entity 'https' named entity 'profiles' named entity 'developed' named entity 'receptor' named entity 'TCR' named entity 'HIV' named entity 'human immunodeficiency virus' named entity 'provide' named entity 'China Life' named entity 'coverage' named entity 'pairing' named entity 'doi' named entity 'long-term' named entity 'people living with HIV' named entity 'quantitative method' named entity 'CD4 +' named entity 'HIV' named entity 'antiretroviral therapy' named entity 'percentile' named entity 'patients' named entity 'PLWH' named entity 'long-term' named entity 'antiretroviral therapy' named entity 'people living with HIV' named entity 'TCR' named entity 'TCR' named entity 'acquired immune deficiency syndrome' named entity 'long-term' named entity 'ART' named entity 'people living with HIV' named entity 'cell receptor'

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