About: Reasoning of spike glycoproteins being more vulnerable to mutations among 158 coronavirus proteins from different species

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Reasoning of spike glycoproteins being more vulnerable to mutations among 158 coronavirus proteins from different species Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Reasoning of spike glycoproteins being more vulnerable to mutations among 158 coronavirus proteins from different species
Creator	Yan, Shaomin Ae, Guang
Source	Medline; PMC
abstract	In this study, we used the probabilistic models developed by us over the last several years to analyze 158 proteins from coronaviruses in order to determine which protein is more vulnerable to mutations. The results provide three lines of evidence suggesting that the spike glycoprotein is different from the other coronavirus proteins: (1) the spike glycoprotein is more sensitive to mutations, this is the current state of the spike glycoprotein, (2) the spike glycoprotein has undergone more mutations in the past, this is the history of spike glycoprotein, and (3) the spike glycoprotein has a bigger potential towards future mutations, this is the future of spike glycoprotein. Furthermore, this study gives a clue on the species susceptibility regarding different proteins. Figure Predictable and unpredictable portions in coronavirus proteins. The data are presented as median with interquartile range. * the predictable and unpredictable portions in spike glycoprotein group are statistically different from any other protein groups at p<0.05 level, except for hemagglutinin-esterase precursor group. # the predictable and unpredictable portions in spike glycoprotein group are statistically different from hemagglutinin-esterase precursor, membrane protein and nucleocapsid protein groups at p<0.05 level. † the predictable and unpredictable portions in spike glycoprotein group are statistically different from hemagglutinin-esterase precursor, and membrane protein groups at p<0.05 level. Electronic Supplementary Material is available for this article if you access the article at http://dx.doi.org/10.1007/s00894-004-0210-0.
has issue date	2004-12-09(xsd:dateTime)
bibo:doi	10.1007/s00894-004-0210-0
bibo:pmid	15592899
has license	no-cc
sha1sum (hex)	3485633379c45f0e4025ebaa7f22903f7b6e769a
schema:url	https://doi.org/10.1007/s00894-004-0210-0
resource representing a document's title	Reasoning of spike glycoproteins being more vulnerable to mutations among 158 coronavirus proteins from different species
has PubMed Central identifier	PMC7088192
has PubMed identifier	15592899
schema:publication	J Mol Model
resource representing a document's body	covid:3485633379c45f0e4025ebaa7f22903f7b6e769a#body_text
is schema:about of	named entity 'CORONAVIRUS' named entity 'mutations' named entity 'susceptibility' named entity 'SPIKE GLYCOPROTEIN' named entity 'SPIKE' named entity 'STUDY' named entity 'RESULTS' named entity 'SUSCEPTIBILITY' named entity 'PROVIDE' named entity 'CORONAVIRUSES' named entity 'POTENTIAL' named entity 'USED' named entity 'CORONAVIRUS' named entity 'YEARS' named entity 'BIGGER' named entity 'ORDER' named entity 'DIFFERENT' named entity 'REASONING' named entity 'GLYCOPROTEINS' named entity '283' named entity 'CURRENT STATE' named entity 'PROTEIN ' named entity 'SENSITIVE TO' named entity 'LINES' named entity 'PROBABILISTIC MODELS' named entity 'MUTATIONS' named entity 'HISTORY OF' named entity 'IN THE PAST' named entity '158' named entity 'VULNERABLE' named entity 'MUTATIONS' named entity 'PROTEINS' named entity 'BEING' named entity 'DETERMINE' named entity 'OF EVIDENCE' named entity 'PROTEINS' named entity 'DIFFERENT' named entity 'SPECIES' named entity '282' named entity '158' named entity 'SPECIES' named entity 'VULNERABLE' named entity 'FUTURE' named entity 'protein' named entity 'current' named entity 'coronavirus' named entity 'history' named entity 'glycoprotein' named entity 'glycoprotein' named entity 'protein' named entity 'amino acid' named entity 'glycoprotein' named entity 'statistical inference' named entity 'glycoprotein' named entity 'sequence alignments' named entity 'protein' named entity 'glycoprotein' named entity 'spike proteins' named entity 'threonines' named entity 'glycoproteins' named entity 'glycoproteins' named entity 'SARS-CoV' named entity 'self-organized' named entity 'hemagglutinin-esterase' named entity 'protein' named entity 'SARS-CoV' named entity 'aminoacid' named entity 'coagulation factor IX' named entity 'haemoglobin' named entity 'virion' named entity 'genome' named entity 'dopamine' named entity 'Kirchhoff's law' named entity 'amino-acid' named entity 'protein' named entity 'coronavirus' named entity 'severe acute respiratory syndrome' named entity 'glycoproteins' named entity 'glycoproteins' named entity 'external factors'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software