About: NF-κB activation by equine arteritis virus is MyD88 dependent and promotes viral replication

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About: NF-κB activation by equine arteritis virus is MyD88 dependent and promotes viral replication Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	NF-κB activation by equine arteritis virus is MyD88 dependent and promotes viral replication
Creator	Baule, Claudia Cholleti, Harindranath Mottahedin, Amin Paidikondala, Maruthibabu
source	Medline; PMC
abstract	NF-κB, a family of transcription factors involved in different cell functions and immune responses is targeted by viruses. The mechanism of NF-κB signalling and its role in replication of EAV have not been investigated. We demonstrate that EAV infection in BHK-21 cells activates NF-κB, and this activation was found to be mediated through the MyD88 pathway. Infection of IKKβ(−/−) murine embryo fibroblasts (MEFs), which are deficient in NF-κB signalling, resulted in lower virus titre, less cytopathic effect, and reduced expression of viral proteins. These findings implicate the MyD88 pathway in EAV-induced NF-κB activation and suggest that NF-κB activation is essential for efficient replication of EAV.
has issue date	2012-11-15(xsd:dateTime)
bibo:doi	10.1007/s00705-012-1515-4
bibo:pmid	23151818
has license	no-cc
sha1sum (hex)	349bde29ae8991f5f2fff50c3250e6d1676eb6de
schema:url	https://doi.org/10.1007/s00705-012-1515-4
resource representing a document's title	NF-κB activation by equine arteritis virus is MyD88 dependent and promotes viral replication
has PubMed Central identifier	PMC7086945
has PubMed identifier	23151818
schema:publication	Arch Virol
resource representing a document's body	covid:349bde29ae8991f5f2fff50c3250e6d1676eb6de#body_text
is schema:about of	named entity 'Infection' named entity 'viral replication' named entity 'MYD88' named entity 'MEDIATED' named entity 'REPLICATION' named entity 'ROLE' named entity 'VIRAL PROTEINS' named entity 'DEFICIENT' named entity 'IKKB' named entity 'ACTIVATION' named entity 'FOUND' named entity 'CELL FUNCTIONS' named entity 'INVESTIGATED' named entity 'DIFFERENT' named entity 'ACTIVATION' named entity 'SUGGEST' named entity 'CELLS' named entity 'BHK-21' named entity 'FAMILY' named entity 'SIGNALLING' named entity 'CYTOPATHIC EFFECT' named entity 'IMMUNE RESPONSES' named entity 'TARGETED' named entity 'EMBRYO' named entity 'EQUINE ARTERITIS VIRUS' named entity 'DEPENDENT' named entity 'VIRAL REPLICATION' named entity 'LOWER' named entity 'EFFICIENT' named entity 'FINDINGS' named entity 'EXPRESSION' named entity 'INFECTION' named entity 'ITS' named entity 'REDUCED' named entity 'FIBROBLASTS' named entity 'MECHANISM' named entity 'TITRE' named entity 'ACTIVATES' named entity 'HAVE' named entity 'THESE' named entity 'PATHWAY' named entity 'MYD88' named entity 'INVOLVED' named entity 'VIRUS' named entity 'INDUCED' named entity 'ESSENTIAL' named entity 'VIRUSES' named entity 'EAV' named entity 'TRANSCRIPTION FACTORS' named entity 'expression' named entity 'viruses' named entity 'virus' named entity 'viral' named entity 'cell' named entity 'family' named entity 'MyD88' named entity 'cell functions' named entity 'viruses' named entity 'IKKb' named entity 'viral replication' named entity 'EAV' named entity 'phosphorylation' named entity 'phosphorylated' named entity 'infection' named entity 'EAV' named entity 'EAV' named entity 'EAV' named entity 'SARS coronavirus' named entity 'antibody' named entity 'kidney' named entity 'EAV' named entity 'wild-type' named entity 'adapter protein' named entity 'nsp3' named entity 'influenza A virus' named entity 'phosphorylated' named entity 'infection' named entity 'p65'

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