About: Specific mucosal IgA immunity in turkey poults infected with turkey coronavirus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Specific mucosal IgA immunity in turkey poults infected with turkey coronavirus
Creator	Hooper, T Schrader, D Wu, C Bryan, T Lin, T Loa, C
Source	Elsevier; Medline; PMC
abstract	The objective of this study was to elucidate the kinetics and magnitudes of specific IgA antibody responses in intestines of turkey poults infected with turkey coronavirus (TCV). Turkey poults were orally inoculated with TCV at 10 days of age. Intestinal segment cultures were administered for duodenum, jejunum, and ileum and the IgA antibody responses were analyzed at 1, 2, 3, 4, 6, or 9 weeks post-infection (PI) in two different experiments. The kinetics of virus-specific IgA antibody responses in duodenum, jejunum, and ileum were similar: gradually increased from 1 week PI, reached the peak at 3 or 4 weeks PI, and declined afterward. The virus-specific IgA antibody responses in duodenum, jejunum, and ileum showed negative correlation with duration of TCV antigen in the corresponding locations of intestine with Spearman’s correlation coefficient of −0.85 (p=0.034), −0.74 (p=0.096), and −0.75 (p=0.084), respectively. Moreover, the virus-specific IgA antibody responses in serum were positively correlated with that of duodenum (coefficient=0.829, p=0.042), jejunum (coefficient=0.829, p=0.042), and ileum (coefficient=0.771, p=0.072) segment cultures, suggesting that the induction of specific IgA response in serum was predictive of an IgA response in intestine. The results indicate that intestinal mucosal IgA antibodies to TCV are elicited in turkeys following infection with TCV. The local mucosal antibodies may provide protective immunity for infected turkeys to recover from TCV infection.
has issue date	2002-09-06(xsd:dateTime)
bibo:doi	10.1016/s0165-2427(02)00135-6
bibo:pmid	12088645
has license	no-cc
sha1sum (hex)	34a0bd91b8e0208d8f9007bad057334cd96ae541
schema:url	https://doi.org/10.1016/s0165-2427%2802%2900135-6
resource representing a document's title	Specific mucosal IgA immunity in turkey poults infected with turkey coronavirus
has PubMed Central identifier	PMC7119794
has PubMed identifier	12088645
schema:publication	Vet Immunol Immunopathol
resource representing a document's body	covid:34a0bd91b8e0208d8f9007bad057334cd96ae541#body_text
is schema:about of	named entity 'IgA' named entity 'coefficient' named entity 'cultures' named entity 'predictive' named entity 'TCV' named entity 'MUCOSAL' named entity 'TURKEY CORONAVIRUS' named entity 'IGA' named entity 'TURKEY CORONAVIRUS' named entity 'RESPONSES' named entity 'STUDY' named entity 'SEGMENT' named entity '9 WEEKS' named entity 'TCV' named entity 'INTESTINAL' named entity 'SPEARMAN' named entity 'POST' named entity 'TURKEY' named entity 'OBJECTIVE' named entity 'PROVIDE' named entity 'AGE' named entity 'PREDICTIVE' named entity 'DUODENUM' named entity 'RESULTS' named entity 'TURKEY' named entity 'LOCAL' named entity 'NEGATIVE' named entity 'INFECTED' named entity 'IMMUNITY' named entity 'AEC' named entity 'WITH DURATION' named entity 'EXPERIMENTS' named entity 'TURKEYS' named entity 'INCREASED' named entity '27S' named entity 'JEJUNUM' named entity 'DAYS' named entity 'ANTIBODIES' named entity 'ILEUM' named entity 'AEC' named entity 'PROTECTIVE IMMUNITY' named entity 'ELICITED' named entity 'SIMILAR' named entity 'CULTURES' named entity 'ORALLY' named entity '3 OR 4' named entity 'VIRUS' named entity 'ANALYZED' named entity 'DIFFERENT' named entity 'MAGNITUDES' named entity 'ADMINISTERED' named entity 'LOCATIONS' named entity 'INTESTINE' named entity 'RESPONSE' named entity 'CORRELATION' named entity 'THE PEAK' named entity 'SERUM' named entity 'FOLLOWING' named entity 'RECOVER' named entity '4 WEEKS' named entity 'ANTIGEN' named entity 'IGA' named entity '1 WEEK' named entity 'POSITIVELY CORRELATED' named entity 'IGA ANTIBODY' named entity 'INDUCTION' named entity 'KINETICS' named entity 'INFECTION' named entity 'COEFFICIENT' named entity 'INTESTINES' named entity '800' named entity 'INFECTED' named entity 'MUCOSAL' covid:arg/34a0bd91b8e0208d8f9007bad057334cd96ae541 named entity 'IgA' named entity 'jejunum'

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