About: Assembly of an integrated human lung cell atlas reveals that SARS-CoV-2 receptor is co-expressed with key elements of the kinin-kallikrein, renin-angiotensin and coagulation systems in alveolar cells

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About: Assembly of an integrated human lung cell atlas reveals that SARS-CoV-2 receptor is co-expressed with key elements of the kinin-kallikrein, renin-angiotensin and coagulation systems in alveolar cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Assembly of an integrated human lung cell atlas reveals that SARS-CoV-2 receptor is co-expressed with key elements of the kinin-kallikrein, renin-angiotensin and coagulation systems in alveolar cells
Creator	Araujo, Eliana Ferruzzi, Adriano Jara, Carlos Lineaus, Von Sidarta-Oliveira, Davi Skaf, Munir Velander, William Velloso, Licio
Source	MedRxiv
abstract	SARS-CoV-2, the pathogenic agent of COVID-19, employs angiotensin converting enzyme-2 (ACE2) as its cell entry receptor. Clinical data reveal that in severe COVID-19, SARS-CoV-2 infects the lung, leading to a frequently lethal triad of respiratory insufficiency, acute cardiovascular failure, and coagulopathy. Physiologically, ACE2 plays a role in the regulation of three systems that could potentially be involved in the pathogenesis of severe COVID-19: the kinin-kallikrein system, resulting in acute lung inflammatory edema; the renin-angiotensin system, promoting cardiovascular instability; and the coagulation system, leading to thromboembolism. Here we analyzed ~130,000 human lung single-cell transcriptomes and show that key elements of the kinin-kallikrein, renin-angiotensin and coagulation systems are co-expressed with ACE2 in alveolar cells, which could explain how changes in ACE2 promoted by SARS-CoV-2 cell entry result in the development of the three most severe clinical components of COVID-19.
has issue date	2020-06-04(xsd:dateTime)
bibo:doi	10.1101/2020.06.02.20120634
has license	medrxiv
sha1sum (hex)	34d847dd92d06c3d409d1d392cc5fc52db35b807
schema:url	https://doi.org/10.1101/2020.06.02.20120634
resource representing a document's title	Assembly of an integrated human lung cell atlas reveals that SARS-CoV-2 receptor is co-expressed with key elements of the kinin-kallikrein, renin-angiotensin and coagulation systems in alveolar cells
resource representing a document's body	covid:34d847dd92d06c3d409d1d392cc5fc52db35b807#body_text
is schema:about of	named entity 'lung' named entity 'kinin-kallikrein system' named entity 'agent' named entity 'involved' named entity 'severe' named entity 'atlas' named entity 'cell' named entity 'SARS-CoV-2' named entity 'reveals' named entity 'acute' named entity 'COVID-19' named entity 'pathogenesis' named entity 'respiratory insufficiency' named entity 'renin-angiotensin system' named entity 'leading' named entity 'cell' named entity 'lung' named entity 'kinin-kallikrein' named entity 'lung' named entity 'cell entry' named entity 'cardiovascular failure' named entity 'respiratory insufficiency' named entity 'COVID-19' named entity 'SARS-CoV-2' named entity 'kinin-kallikrein' named entity 'CTSL' named entity 'cell types' named entity 'alveolar cells' named entity 'angiotensin' named entity 'COVID-19' named entity 'ThinkPad' named entity 'AGT' named entity 'TMPRSS2' named entity 'Bradykinin' named entity 'KLKB1' named entity 'AGTR1' named entity 'effector' named entity 'KKS' named entity 'type 1' named entity 'ACE2' named entity 'ACE inhibitors' named entity 'RStudio' named entity 'plasmin' named entity 'peer review' named entity 'AGTR1' named entity 'medRxiv' named entity 'preprint' named entity 'cell types' named entity 'ACE2' named entity 'TPCN2' named entity 'lysosome' named entity 'kallikrein' named entity '20%' named entity 'alveolar cells' named entity 'lymph vessel' named entity 'preprint' named entity 'serine protease' named entity '2.1' named entity 'ACE inhibitors' named entity 'edema' named entity 'KKS' named entity 'D-dimer' named entity 'peptide' named entity 'COVID-19' named entity 'prognosis' named entity 'bradykinin' named entity 'spike protein' named entity 'AGTR1' named entity 'high-performance computing' named entity 'intensive care unit' named entity 'PAI-1' named entity 'Renin' named entity 'ACE2' named entity 'preprint' named entity 'serine protease' named entity 'preprint' named entity 'ACE2' named entity 'enzyme'

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