About: IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation

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About: IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation
Creator	Crompton, Tessa Furmanski, Anna Barbarulo, Alessandro Barenco, Martino Ono, Masahiro Papaioannou, Eleftheria Powell, Rebecca Ross, Susan Sahni, Hemant Solanki, Anisha Adams, David D'acquisto, Fulvio Lange, Ulrike Lau, Ching-In Yánez, Diana
Source	PMC
abstract	The interferon‐inducible transmembrane (Ifitm/Fragilis) genes encode homologous proteins that are induced by IFNs. Here, we show that IFITM proteins regulate murine CD4(+) Th cell differentiation. Ifitm2 and Ifitm3 are expressed in wild‐type (WT) CD4(+) T cells. On activation, Ifitm3 was downregulated and Ifitm2 was upregulated. Resting Ifitm‐family‐deficient CD4(+) T cells had higher expression of Th1‐associated genes than WT and purified naive Ifitm‐family‐deficient CD4(+) T cells differentiated more efficiently to Th1, whereas Th2 differentiation was inhibited. Ifitm‐family‐deficient mice, but not Ifitm3‐deficient mice, were less susceptible than WT to induction of allergic airways disease, with a weaker Th2 response and less severe disease and lower Il4 but higher Ifng expression and IL‐27 secretion. Thus, the Ifitm family is important in adaptive immunity, influencing Th1/Th2 polarization, and Th2 immunopathology.
has issue date	2018-11-09(xsd:dateTime)
bibo:doi	10.1002/eji.201847692
bibo:pmid	30365177
has license	cc-by
sha1sum (hex)	34e218f77932d4c7a4c29c7a18010d846ee3f4a6
schema:url	https://doi.org/10.1002/eji.201847692
resource representing a document's title	IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation
has PubMed Central identifier	PMC6396086
has PubMed identifier	30365177
schema:publication	Eur J Immunol
resource representing a document's body	covid:34e218f77932d4c7a4c29c7a18010d846ee3f4a6#body_text
is schema:about of	named entity 'DRIVE' named entity 'allergic' named entity 'regulate' named entity 'naive' named entity 'differentiation' named entity 'allergic' named entity 'Basic' named entity 'EXACERBATE' named entity 'ARTICLE' named entity 'IFNG' named entity 'CELL DIFFERENTIATION' named entity 'TRANSMEMBRANE' named entity 'ADAPTIVE IMMUNITY' named entity 'WILD-TYPE' named entity 'ALLERGIC' named entity 'ACTIVATION' named entity 'IMMUNOPATHOLOGY' named entity 'INTERFERON' named entity 'TH2' named entity 'PROTEINS' named entity 'IMPORTANT' named entity 'POLARIZATION' named entity 'T CELLS' named entity 'HERE' named entity 'DEFICIENT' named entity 'EXPRESSION' named entity 'SUSCEPTIBLE' named entity 'GENES' named entity 'INDUCIBLE' named entity 'BASIC' named entity 'FAMILY' named entity 'MICE' named entity 'BUT' named entity 'CD4' named entity 'INHIBITED' named entity 'TH2 RESPONSE' named entity 'ENCODE' named entity 'ADAPTIVE IMMUNITY' named entity 'CELL DIFFERENTIATION' named entity 'RESEARCH' named entity 'INDUCED' named entity 'AIRWAYS DISEASE' named entity 'DIFFERENTIATED' named entity 'IFITM3' named entity 'HOMOLOGOUS' named entity 'RESTING' named entity 'TH1' named entity 'IFITM2' named entity 'INDUCTION' named entity 'TH CELL' named entity 'EXPRESSED' named entity 'SEVERE DISEASE' named entity 'LOWER' named entity 'PROTEINS' named entity 'UPREGULATED' named entity 'IL-27 SECRETION' named entity 'IL4' named entity 'PURIFIED' named entity 'ASSOCIATED' named entity 'DIFFERENTIATION' named entity 'TYPE 2' named entity 'ALLERGIC AIRWAY INFLAMMATION' named entity 'T HELPER CELL' named entity 'REGULATE' named entity 'HIGHER' named entity 'MURINE' covid:arg/34e218f77932d4c7a4c29c7a18010d846ee3f4a6

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