About: Direct structural evidence for formation of a stem-loop structure involved in ribosomal frameshifting in human immunodeficiency virus type 1 1 Kumho Life and Environmental Science Laboratory Publication No. 8. 1

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About: Direct structural evidence for formation of a stem-loop structure involved in ribosomal frameshifting in human immunodeficiency virus type 1 1 Kumho Life and Environmental Science Laboratory Publication No. 8. 1 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Direct structural evidence for formation of a stem-loop structure involved in ribosomal frameshifting in human immunodeficiency virus type 1 1 Kumho Life and Environmental Science Laboratory Publication No. 8. 1
Creator	Kang, Hunseung
source	Elsevier; Medline; PMC
abstract	Abstract Programmed ribosomal frameshifting in viral messenger RNA occurs in response to neighboring sequence elements consisting of: a frameshift site, a spacer, and a downstream enhancer sequence. In human immunodeficiency virus type 1 (HIV-1) mRNA, this sequence element has a potential to form either a stem-loop or a pseudoknot structure. Based on many mutational studies, the stem-loop structure has been proposed for the downstream enhancer region of the HIV-1 mRNA. This stimulatory stem-loop structure is separated from the shift site by a spacer of seven nucleotides. In contrast, a recent report has proposed an alternative model in which the bases in the spacer sequence form a pseudoknot structure as the downstream enhancer sequence [Du et al., Biochemistry 35 (1996) 4187–4198.]. Using UV melting and enzymatic mapping analyses, we have investigated the conformation of the sequence region involved in ribosomal frameshifting in HIV-1. Our S1, V1, and T1 endonuclease mappings, together with UV melting analysis, clearly indicate that this sequence element of the HIV-1 mRNA frameshift site forms a stem-loop structure, not a pseudoknot structure. This finding further supports the stem-loop structure proposed by many mutational studies for the downstream enhancer sequence of the HIV-1 mRNA.
has issue date	1998-04-01(xsd:dateTime)
bibo:doi	10.1016/s0167-4781(98)00004-9
bibo:pmid	9545540
has license	els-covid
sha1sum (hex)	3517177d654c706a71267c27e311ec2766537334
schema:url	https://doi.org/10.1016/s0167-4781%2898%2900004-9
resource representing a document's title	Direct structural evidence for formation of a stem-loop structure involved in ribosomal frameshifting in human immunodeficiency virus type 1 1 Kumho Life and Environmental Science Laboratory Publication No. 8. 1
has PubMed Central identifier	PMC7148724
has PubMed identifier	9545540
schema:publication	Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
resource representing a document's body	covid:3517177d654c706a71267c27e311ec2766537334#body_text
is schema:about of	named entity 'viral' named entity 'potential' named entity 'structure' named entity 'HIV-1' named entity 'ELEMENTS' named entity 'SHIFT' named entity 'CONTRAST' named entity 'HIV-1 MRNA' named entity 'ELEMENT' named entity 'RESPONSE TO' named entity 'SEPARATED FROM' named entity 'BASES' named entity 'SPACER' named entity 'STEM-LOOP' covid:arg/3517177d654c706a71267c27e311ec2766537334 named entity 'HUMAN IMMUNODEFICIENCY VIRUS TYPE 1' named entity 'INVOLVED' named entity 'FORMATION' named entity 'PSEUDOKNOT' named entity 'ENHANCER REGION' named entity 'REPORT' named entity 'VIRAL' named entity 'RIBOSOMAL' named entity 'BASED' named entity 'NUCLEOTIDES' named entity 'RECENT' named entity 'NEIGHBORING' named entity 'DIRECT' named entity 'EVIDENCE FOR' named entity 'RIBOSOMAL' named entity 'ALTERNATIVE' named entity 'STRUCTURE' named entity 'POTENTIAL' named entity 'STRUCTURAL' named entity 'DOWNSTREAM ENHANCER' named entity 'EITHER' named entity 'STUDIES' named entity 'SEQUENCE' named entity 'TO FORM' named entity 'MODEL' named entity 'FRAMESHIFT' named entity 'SITE' named entity 'STEM-LOOP STRUCTURE' named entity 'FORM' named entity 'SEVEN' named entity 'STEM-LOOP STRUCTURE' named entity 'HUMAN IMMUNODEFICIENCY VIRUS TYPE 1' named entity 'MESSENGER RNA' named entity 'PROPOSED' named entity 'structure' named entity 'studies' named entity 'messenger RNA' named entity 'mRNA' named entity 'enhancer region' named entity 'stem-loop structure' named entity 'stem-loop structure' named entity 'MgCl' named entity 'mRNA' named entity 'RNA structure' named entity 'secondary structure' named entity 'pseudoknot' named entity 'frameshifting' named entity 'nucleotides' named entity 'stem-loop' named entity 'denaturing' named entity 'RNase' named entity 'frameshifting' named entity 'RNA' named entity 'denaturing' named entity 'xylene cyanol' named entity 'HTLV-II' named entity 'frameshift' named entity 'stem-loop structure' named entity 'cleavage pattern' named entity 'absorbance' named entity 'algorithm' named entity 'conformation' named entity 'frameshifting' named entity 'polyacrylamide gel electrophoresis' named entity 'FIV' named entity 'enhancer sequence'

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