About: Nanomaterial Effects on Viral Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Nanomaterial Effects on Viral Infection
Creator	Chen, Hao Chen, H Lednicky, John Lednicky, J Humes, Sara Humes, · Sabo-Attwood, Tara Sabo-Attwood, · Saleh, N Saleh, Navid
Source	PMC
abstract	The potential for environmental and occupational exposures of populations to nanomaterials (NMs) has fostered concerns of associated adverse health effects, with a particular emphasis on pulmonary injury and disease. Many studies have revealed that several types of NMs can evoke a variety of biological responses, such as pulmonary inflammation and oxidative stress, which contribute to allergy, fibrosis, and granuloma formation. Less attention has been paid to health effects that may result from exposure to NMs and additional stressors such as pathogens, with a particular focus on susceptibility to viral infection. This chapter will summarize the current body of literature related to NMs and viral exposures with a primary focus on immune modulation. A summary of the studies performed and major findings to date will be discussed, highlighting proposed molecular mechanisms behind NM-driven host susceptibility, challenges, limitations, and future research needs. Specific mechanisms discussed include direct interaction between NMs and biological molecules, activation of pattern recognition receptors (PRRs) and related signaling pathways, production of oxidative stress and mitochondrial dysfunction, inflammasome activation, and modulation of lipid signaling networks.
has issue date	2020-01-31(xsd:dateTime)
bibo:doi	10.1007/978-3-030-33962-3_10
has license	no-cc
sha1sum (hex)	35216abe0a88edda40c6249dd732c68d60dc9e8c
schema:url	https://doi.org/10.1007/978-3-030-33962-3_10
resource representing a document's title	Nanomaterial Effects on Viral Infection
has PubMed Central identifier	PMC7122331
schema:publication	Interaction of Nanomaterials with the Immune System
resource representing a document's body	covid:35216abe0a88edda40c6249dd732c68d60dc9e8c#body_text
is schema:about of	named entity 'health effects' named entity 'formation' named entity 'pattern recognition receptors (PRRs)' named entity 'EXPOSURES' named entity 'PAID' named entity 'FOCUS' named entity 'RELATED' named entity 'SIGNALING PATHWAYS' named entity 'BIOLOGICAL' named entity 'LIMITATIONS' named entity 'PULMONARY INFLAMMATION' named entity 'ASSOCIATED' named entity 'SUSCEPTIBILITY' named entity 'BODY' named entity 'MAJOR' named entity 'HAVE' named entity 'LIPID SIGNALING' named entity 'BIOLOGICAL MOLECULES' named entity 'POPULATIONS' named entity 'STRESSORS' named entity 'MOLECULAR' named entity 'PULMONARY INJURY' named entity 'RESULT' named entity 'OXIDATIVE STRESS' named entity 'NANOMATERIALS' named entity 'CHAPTER' named entity 'PROPOSED' named entity 'INCLUDE' named entity 'CONTRIBUTE ' named entity 'DIRECT INTERACTION' named entity 'HIGHLIGHTING' named entity 'OCCUPATIONAL EXPOSURES' named entity 'SPECIFIC' named entity 'EFFECTS' named entity 'ALLERGY' named entity 'GRANULOMA FORMATION' named entity 'LITERATURE' named entity 'ATTENTION' named entity 'FINDINGS' named entity 'VARIETY' named entity 'EFFECTS' named entity 'NANOMATERIAL' named entity 'CHALLENGES' named entity 'PATHOGENS' named entity 'RESPONSES' named entity 'DRIVEN' named entity 'MITOCHONDRIAL DYSFUNCTION' named entity 'SUSCEPTIBILITY TO VIRAL INFECTION' named entity 'CURRENT' named entity 'FIBROSIS' named entity 'IMMUNE MODULATION' named entity 'VIRAL' named entity 'MODULATION' named entity 'TYPES' named entity 'ADDITIONAL' named entity 'NMS' named entity 'FUTURE' named entity 'REVEALED' named entity 'MECHANISMS' named entity 'RESEARCH NEEDS' named entity 'INFLAMMASOME ACTIVATION' named entity 'SIGNALING NETWORKS' named entity 'VIRAL INFECTION' named entity 'PRIMARY FOCUS' named entity 'CONCERNS' named entity 'PRODUCTION' named entity 'STUDIES' named entity 'EXPOSURE TO' named entity 'ENVIRONMENTAL' named entity 'POTENTIAL' named entity 'FOSTERED' named entity 'PATTERN RECOGNITION RECEPTORS' named entity 'SUMMARY' named entity 'ACTIVATION'

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