About: Synthesis and anticonvulsant properties of 1-(amino-N-arylmethanethio)-3-(1-substituted benzyl-2, 3-dioxoindolin-5-yl) urea derivatives

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Synthesis and anticonvulsant properties of 1-(amino-N-arylmethanethio)-3-(1-substituted benzyl-2, 3-dioxoindolin-5-yl) urea derivatives Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Synthesis and anticonvulsant properties of 1-(amino-N-arylmethanethio)-3-(1-substituted benzyl-2, 3-dioxoindolin-5-yl) urea derivatives
Creator	Siddiqui, Nadeem Alam, M Stables, James
Source	Elsevier; Medline; PMC
abstract	Abstract Various 1-(amino-N-arylmethanethio)-3-(1-substituted benzyl-2, 3-dioxoindolin-5-yl) urea (5a–p) were designed keeping in view the structural requirements suggested in the pharmacophore model for anticonvulsant activity. Their in vivo anticonvulsant screenings were performed by two most adopted seizure models, maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ). Compound 5f was found active in MES screening while compounds 5h, 5i, 5k and 5l showed significant anticonvulsant activity in both the screenings and were devoid of any neurotoxicity. Compound 5h and 5i showed marked protection at 300mg/kg against MES and scPTZ screening. Compound 5i also showed protection against MES screening at the dose of 100mg/kg. In 6Hz screening these two compounds showed significant protection and emerged as lead compounds for future investigations.
has issue date	2011-06-30(xsd:dateTime)
bibo:doi	10.1016/j.ejmech.2011.03.004
bibo:pmid	21435751
has license	els-covid
sha1sum (hex)	354666aaa96fa3ccef197692d1ffbfc635878c51
schema:url	https://doi.org/10.1016/j.ejmech.2011.03.004
resource representing a document's title	Synthesis and anticonvulsant properties of 1-(amino-N-arylmethanethio)-3-(1-substituted benzyl-2, 3-dioxoindolin-5-yl) urea derivatives
has PubMed Central identifier	PMC7115639
has PubMed identifier	21435751
schema:publication	European Journal of Medicinal Chemistry
resource representing a document's body	covid:354666aaa96fa3ccef197692d1ffbfc635878c51#body_text
is schema:about of	named entity 'seizure' named entity 'activity' named entity 'UREA DERIVATIVES' named entity 'INVESTIGATIONS' named entity 'PERFORMED BY' named entity 'ACTIVE' named entity 'MES' named entity 'PENTYLENETETRAZOLE' named entity 'ADOPTED' named entity 'SIGNIFICANT' named entity 'PHARMACOPHORE MODEL' named entity 'ANTICONVULSANT' named entity 'VARIOUS' named entity 'REQUIREMENTS' named entity 'SYNTHESIS' named entity 'PROPERTIES' named entity 'SEIZURE' named entity '100' named entity 'NEUROTOXICITY' named entity 'MARKED' named entity 'MODELS' named entity 'BENZYL' named entity 'BENZYL' named entity 'SCREENINGS' named entity 'MAXIMAL' named entity 'LEAD COMPOUNDS' named entity 'UREA' named entity 'ELECTROSHOCK' named entity 'MG%' named entity 'SCREENING' named entity 'FUTURE' named entity 'COMPOUND' named entity 'ACTIVITY' named entity 'DOSE' named entity 'ANTICONVULSANT' named entity '300' named entity 'VIEW' named entity 'THEIR' named entity 'PROTECTION' named entity 'SUBCUTANEOUS' named entity 'STRUCTURAL' named entity 'THESE' named entity 'FOUND' named entity 'IN VIVO' covid:arg/354666aaa96fa3ccef197692d1ffbfc635878c51 named entity 'Compound' named entity 'screenings' named entity 'screenings' named entity 'urea' named entity 'screening' named entity 'seizure' named entity 'electroshock' named entity 'anticonvulsant' named entity 'models' named entity 'screening' named entity 'pentylenetetrazole' named entity 'neurotoxicity' named entity 'electroshock' named entity 'seizure' named entity 'benzyl' named entity 'urea derivatives' named entity 'AED' named entity 'India' named entity 'physicochemical' named entity 'ppm' named entity 'refluxing' named entity 'Anticonvulsant' named entity 'anticonvulsant' named entity 'lipophilic' named entity 'anticonvulsant' named entity 'epilepsy' named entity 'partition coefficient' named entity '2, 3' named entity 'pharmacophoric' named entity 'HCl' named entity 'electron' named entity 'Nitrogen' named entity 'Sodium valproate' named entity '2, 3'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software