About: Clinical evaluation of potential usefulness of serum lactate dehydrogenase (LDH) in 2019 novel coronavirus (COVID-19) pneumonia

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About: Clinical evaluation of potential usefulness of serum lactate dehydrogenase (LDH) in 2019 novel coronavirus (COVID-19) pneumonia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Clinical evaluation of potential usefulness of serum lactate dehydrogenase (LDH) in 2019 novel coronavirus (COVID-19) pneumonia
Creator	Wang, Yi Chen, Cheng Yao, Lin Tang, Pei-Jun Wang, Xia-Fang Wu, Mei-Ying Zhu, Xin-Yun
source	Medline; PMC
abstract	BACKGROUND: There was much evidence suggesting that the serum lactate dehydrogenase (LDH) levels reflect the extent of various pathophysiological processes. However, the current information about dynamic change of LDH in COVID-19 pneumonia has not been well investigated. METHODS: Study was performed in 87 cases confirmed by COVID-19 infection. The serum LDH levels were determined at diagnosis and follow-up visits. The evaluation of clinical response to therapy was based on chest CT scan. We selected the value of LDH around the data of chest CT scan (− 1 ~ + 1 day). RESULTS: At diagnosis, significant differences in LDH levels were found between non-severe and severe group (P < 0.05). It was demonstrated that increase or decrease of LDH was indicative of radiographic progress or improvement (P < 0.05). The time to LDH normalization (5.67 ± 0.55, days) was positively correlated with the time to radiographic absorption (5.57 ± 0.65 days, r = 0.53, P < 0.05). Applying the cut-off value of the increase in LDH has good specificity to predict disease progression. CONCLUSIONS: Serum LDH was validated for its potential usefulness as markers for evaluating clinical severity and monitoring treatment response in COVID-19 pneumonia.
has issue date	2020-07-06(xsd:dateTime)
bibo:doi	10.1186/s12931-020-01427-8
bibo:pmid	32631317
has license	cc-by
sha1sum (hex)	35576e496cd416006d2f647582230f0ff103ba1d
schema:url	https://doi.org/10.1186/s12931-020-01427-8
resource representing a document's title	Clinical evaluation of potential usefulness of serum lactate dehydrogenase (LDH) in 2019 novel coronavirus (COVID-19) pneumonia
has PubMed Central identifier	PMC7336103
has PubMed identifier	32631317
schema:publication	Respir Res
resource representing a document's body	covid:35576e496cd416006d2f647582230f0ff103ba1d#body_text
is schema:about of	named entity 'EVIDENCE' named entity 'LDH' named entity 'pneumonia' named entity 'lactate dehydrogenase' named entity 'Clinical evaluation' named entity 'chest scan' named entity 'viral illness' named entity 'TRA' named entity 'LDH' named entity 'medical history' named entity 'cut-off' named entity 'lactate' named entity 'ARDS' named entity 'LDH' named entity 'Lactate dehydrogenase' named entity 'serum' named entity 'risk factors' named entity 'LDH' named entity 'LDH' named entity 'LDH' named entity 'LDH' named entity 'COVID' named entity 'serum' named entity 'LDH' named entity 'inflammatory response' named entity 'cellular death' named entity 'serum' named entity 'sputum' named entity 'coronavirus' named entity 'respiratory disease' named entity 'COVID-19' named entity 'fatigue' named entity 'serum' named entity 'LDH' named entity 'pneumonia' named entity 'Lactate dehydrogenase' named entity 'LDH' named entity 'pneumonia' named entity 'COVID' named entity 'pneumonia' named entity 'body tissues' named entity 'LDH' named entity 'pneumonia' named entity 'chest CT scan' named entity 'COVID' named entity 'LDH' named entity 'chest CT scan' named entity 'coagulation' named entity 'LDH' named entity 'COVID' named entity 'LDH' named entity 'comorbidities' named entity 'LDH' named entity 'tissue breakdown' named entity 'steroid' named entity 'LDH' named entity 'COVID' named entity 'hemolysis' named entity 'CT image' named entity 'necrosis' named entity 'LDH' named entity 'pneumonia' named entity 'infectious disease' named entity 'CT scans' named entity 'airway' named entity 'follow-up' named entity '0.01' named entity 'TRA' named entity 'diabetes' named entity 'LDH' named entity 'LDH' named entity 'dyspnea' named entity 'inflammatory responses' named entity 'idiopathic pulmonary fibrosis' named entity 'creatinine levels'

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