About: Persistent viremia by a novel parvovirus in a slow loris (Nycticebus coucang) with diffuse histiocytic sarcoma

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Persistent viremia by a novel parvovirus in a slow loris (Nycticebus coucang) with diffuse histiocytic sarcoma Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Persistent viremia by a novel parvovirus in a slow loris (Nycticebus coucang) with diffuse histiocytic sarcoma
Creator	Canuti, Marta Tijssen, Peter Jebbink, Maarten Oude Munnink, Bas Coombs, Kevin Farsani, Jazaeri Mohammad, Seyed Van Der Hoek, Lia Cullen, John Gadi, Sashi Williams, Cathy
Source	PMC
abstract	Cancer is one of the leading health concerns for human and animal health. Since the tumorigenesis process is not completely understood and it is known that some viruses can induce carcinogenesis, it is highly important to identify novel oncoviruses and extensively study underlying oncogenic mechanisms. Here, we investigated a case of diffuse histiocytic sarcoma in a 22 year old slow loris (Nycticebus coucang), using a broad spectrum virus discovery technique. A novel parvovirus was discovered and the phylogenetic analysis performed on its fully sequenced genome demonstrated that it represents the first member of a novel genus. The possible causative correlation between this virus and the malignancy was further investigated and 20 serum and 61 organ samples from 25 animals (N. coucang and N. pygmaeus) were screened for the novel virus but only samples collected from the originally infected animal were positive. The virus was present in all tested organs (intestine, liver, spleen, kidneys, and lungs) and in all banked serum samples collected up to 8 years before death. All attempts to identify a latent viral form (integrated or episomal) were unsuccessful and the increase of variation in the viral sequences during the years was consistent with absence of latency. Since it is well known that parvoviruses are dependent on cell division to successfully replicate, we hypothesized that the virus could have benefitted from the constantly dividing cancer cells and may not have been the cause of the histiocytic sarcoma. It is also possible to conjecture that the virus had a role in delaying the tumor progression and this report might bring new exciting opportunities in recognizing viruses to be used in cancer virotherapy.
has issue date	2014-12-01(xsd:dateTime)
bibo:doi	10.3389/fmicb.2014.00655
bibo:pmid	25520709
has license	cc-by
sha1sum (hex)	3559efd0d0327a8262022dcdd40d01a6f468cb82
schema:url	https://doi.org/10.3389/fmicb.2014.00655
resource representing a document's title	Persistent viremia by a novel parvovirus in a slow loris (Nycticebus coucang) with diffuse histiocytic sarcoma
has PubMed Central identifier	PMC4249460
has PubMed identifier	25520709
schema:publication	Front Microbiol
resource representing a document's body	covid:3559efd0d0327a8262022dcdd40d01a6f468cb82#body_text
is schema:about of	named entity 'member' named entity 'animal' named entity 'positive' named entity 'virus' named entity 'causative' named entity 'recognizing' named entity 'serum' named entity 'extensively' named entity 'demonstrated' named entity 'conjecture' named entity 'liver' named entity 'mechanisms' covid:arg/3559efd0d0327a8262022dcdd40d01a6f468cb82 named entity 'animals' named entity 'cancer' named entity 'performed' named entity 'genome' named entity 'human' named entity 'tumorigenesis' named entity 'represents' named entity 'oncogenic' named entity 'viral' named entity 'leading' named entity 'tumor progression' named entity 'virus' named entity 'oncoviruses' named entity 'animal health' named entity 'slow loris' named entity 'tumorigenesis' named entity 'serum' named entity 'genus' named entity 'cancer cells' named entity 'correlation' named entity 'viremia' named entity 'Nycticebus coucang' named entity 'phylogenetic inference' named entity 'Thermo Scientific' named entity 'dendritic cells' named entity 'genome' named entity 'genomes' named entity 'genus' named entity 'Slow Loris' named entity 'Toxoplasma gondii' named entity 'lymph nodes' named entity 'Maximum Likelihood' named entity 'bone marrow' named entity 'stop codon' named entity 'Lusby' named entity 'anisocytosis' named entity 'T4 DNA ligase' named entity 'nucleotide sequence' named entity 'Tetraparvovirus' named entity 'formal proof' named entity 'genome' named entity 'viremia' named entity 'parvovirus' named entity 'DNA polymerase' named entity 'mammals' named entity 'DNA polymerase' named entity 'subfamily' named entity 'spleen' named entity 'episomal' named entity 'restriction enzymes' named entity 'Parvovirinae' named entity 'amino acid' named entity 'Indonesia' named entity 'macrophages' named entity 'histiocytes' named entity 'genome' named entity 'centrifugation' named entity 'Big Dye terminator'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software